Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.38 |
| ▸ | FLT1 | P17948 | 10/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10272603 | 0.84 | MET (0.38) | KDR | |
| SCHEMBL3560063 | 0.80 | PDGFRA (0.46) | KDRPDGFRA | |
| SCHEMBL13258725 | 0.78 | GSK3B (0.38) | KDRFLT1 | |
| SCHEMBL13185260 | 0.74 | KDR (0.38) | KDRFLT1 | |
| SCHEMBL13254390 | 0.69 | LTA4H (0.44) | KDRFLT1 | |
| SCHEMBL10202848 | 0.68 | KDR (0.38) | KDRFLT1 | |
| SCHEMBL13185317 | 0.68 | MET (0.40) | KDR | |
| SCHEMBL13185405 | 0.68 | MET (0.38) | KDR | |
| SCHEMBL13185382 | 0.68 | MET (0.39) | KDR | |
| SCHEMBL22866542 | 0.68 | NPC1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216766-A1 | Inhibitors of VEGF Receptor and HGF Receptor Signalling | 92229129 QUEBEC INC. (CA) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216766-A1 | Inhibitors of VEGF Receptor and HGF Receptor Signalling | HGF, MET, FLT1 | KDR 4/4885FLT1 3/4885PDGFRB 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.