Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 17/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2060609 | 0.86 | TRPM8 (0.43) | TRPM8NR3C1CNR2 | |
| SCHEMBL2061062 | 0.86 | TRPM8 (0.44) | TRPM8NR3C1 | |
| SCHEMBL10280383 | 0.85 | TRPM8 (0.47) | TRPM8NR3C1 | |
| SCHEMBL1098674 | 0.83 | NR3C1 (0.54) | TRPM8NR3C1CNR2 | |
| SCHEMBL2060913 | 0.82 | TRPM8 (0.45) | TRPM8 | |
| SCHEMBL2786001 | 0.82 | TRPM8 (0.42) | TRPM8NR3C1CNR2 | |
| SCHEMBL2060713 | 0.80 | TRPM8 (0.54) | TRPM8NR3C1 | |
| SCHEMBL1099967 | 0.73 | NR3C1 (0.50) | TRPM8NR3C1SERPINE1 | |
| SCHEMBL1098696 | 0.69 | PGR (0.52) | NR3C1CNR2 | |
| SCHEMBL1148790 | 0.69 | TRPM8 (0.46) | TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010080398-A1 | SULFONAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-07-15 | — | — | WO | disclosed |