SCHEMBL1326327

SCHEMBL1326327

CC(=O)CCCCCC(N)=O

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PAOX Q6QHF9 5/20 0.67
ALDH1A1 P00352 1/20 0.50
SOAT1 P35610 2/20 0.48
MEN1 O00255 1/20 0.48
FAAH O00519 1/20 0.48
TP53 P04637 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2C19 P33261 1/20 0.48
KMT2A Q03164 1/20 0.48
ACHE P22303 1/20 0.46
KDM4E B2RXH2 2/20 0.43
LMNA P02545 3/20 0.41
SLC15A2 Q16348 1/20 0.41
PMP22 Q01453 2/20 0.39
ALOX15 P16050 1/20 0.39
BLM P54132 1/20 0.39
TSHR P16473 1/20 0.38
NFKB1 P19838 1/20 0.38
CES2 O00748 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9410608 1.00 PAOX (0.67) PAOXALDH1A1SOAT1MEN1FAAH
SCHEMBL12488391 1.00 PAOX (0.67) PAOXALDH1A1SOAT1MEN1FAAH
SCHEMBL22423301 1.00 PAOX (0.67) PAOXALDH1A1SOAT1MEN1FAAH
SCHEMBL30628038 1.00 PAOX (0.67) PAOXALDH1A1SOAT1MEN1FAAH
SCHEMBL9410599 1.00 PAOX (0.67) PAOXALDH1A1SOAT1MEN1FAAH
SCHEMBL23352440 1.00 PAOX (0.67) PAOXALDH1A1SOAT1MEN1FAAH
SCHEMBL3318564 1.00 PAOX (0.67) PAOXALDH1A1SOAT1MEN1FAAH
SCHEMBL1327434 0.97 PAOX (0.62) PAOXALDH1A1SOAT1MEN1FAAH
Acetic Acid SCHEMBL28338186 0.95 PAOX (0.61) PAOXALDH1A1SOAT1MEN1FAAH
SCHEMBL1326107 0.91

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110144033-A1 Proteasome Inhibitors and Methods of Using the Same CEPHALON, INC. (US) 2011-06-16 US claimed
US-7915236-B2 Proteasome inhibitors and methods of using the same CEPHALON, INC. (US) 2011-03-29 US claimed
EP-1660507-B9 PROTEASOME INHIBITORS AND METHODS OF USING THE SAME CEPHALON INC (US) 2010-03-24 EP claimed
US-20090291918-A1 PROTEASOME INHIBITORS AND METHODS OF USING THE SAME CEPHALON, INC. (US) 2009-11-26 US claimed
EP-1660507-B1 PROTEASOME INHIBITORS AND METHODS OF USING THE SAME CEPHALON INC (US) 2009-08-05 EP claimed
EP-1660507-A2 PROTEASOME INHIBITORS AND METHODS OF USING THE SAME CEPHALON, INC. (US) 2006-05-31 EP claimed
US-20050107307-A1 Proteasome inhibitors and methods of using the same TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2005-05-19 US claimed
WO-2005021558-A2 PROTEASOME INHIBITORS AND METHODS OF USING THE SAME CEPHALON, INC. (US) 2005-03-10 WO claimed
EP-0772617-B1 7-O-CARBAMOYL HEPTOSE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AND SCREENING PROCESS FOR THEIR DETECTION FORSCH BORSTEL INST FUER EXPER (DE) 1999-06-23 EP claimed
US-20240285584-A1 AMIDE DERIVATIVES OF N-UREA SUBSTITUTED AMINO ACIDS AS FORMYL PEPTIDERECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS ALLERGAN, INC. 2024-08-29 US disclosed
US-20220202777-A1 AMIDE DERIVATIVES OF N-UREA SUBSTITUTED AMINO ACIDS AS FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS ALLERGAN, INC. 2022-06-30 US disclosed
US-10993931-B2 Amide derivatives of N-urea substituted amino acids as formyl peptide receptor like-1 (FPRL-1) receptor modulators ALLERGAN, INC. (US) 2021-05-04 US disclosed
US-20190343804-A1 AMIDE DERIVATIVES OF N-UREA SUBSTITUTED AMINO ACIDS AS FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS ALLERGAN, INC. 2019-11-14 US disclosed
US-10172832-B2 Amide derivatives of N-urea substituted amino acids as formyl peptide receptor like-1 (FPRL-1) receptor modulators ALLERGAN, INC. (US) 2019-01-08 US disclosed
US-20050107307-A1 Proteasome inhibitors and methods of using the same TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2005-05-19 US disclosed
US-5891892-A Small molecule biaryl compounds as inhibitors of endothelin converting enzyme WARNER-LAMBERT COMPANY (US) 1999-04-06 US disclosed
EP-0772617-A1 7-O-CARBAMOYL HEPTOSE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AND SCREENING PROCESS FOR THEIR DETECTION Forschungsinstitut Borstel Institut für Experimentelle Biologie und Medizin (DE) 1997-05-14 EP disclosed
EP-0772617-A1 7-O-CARBAMOYL HEPTOSE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AND SCREENING PROCESS FOR THEIR DETECTION Forschungsinstitut Borstel Institut für Experimentelle Biologie und Medizin (DE) 1997-05-14 EP disclosed
WO-1996002550-A1 7-O-CARBAMOYL HEPTOSE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AND SCREENING PROCESS FOR THEIR DETECTION FORSCHUNGSINSTITUT BORSTEL INSTITUT FÜR EXPERIMENTELLE BIOLOGIE UND MEDIZIN (DE) 1996-02-01 WO disclosed
WO-1996002550-A1 7-O-CARBAMOYL HEPTOSE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AND SCREENING PROCESS FOR THEIR DETECTION FORSCHUNGSINSTITUT BORSTEL INSTITUT FÜR EXPERIMENTELLE BIOLOGIE UND MEDIZIN (DE) 1996-02-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090291918-A1 PROTEASOME INHIBITORS AND METHODS OF USING THE SAME PSMB11, PSMB5, PSMB6 PAOX 1819/4885ALDH1A1 3935/4885SOAT1 3753/4885
US-20050107307-A1 Proteasome inhibitors and methods of using the same PSMB11, PSMB5, PSMB6 PAOX 1819/4885ALDH1A1 3935/4885SOAT1 3753/4885
US-20190343804-A1 AMIDE DERIVATIVES OF N-UREA SUBSTITUTED AMINO ACIDS AS FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS FPR1, FPR3, FPR2 PAOX 2393/4885ALDH1A1 4424/4885SOAT1 3506/4885
US-10172832-B2 Amide derivatives of N-urea substituted amino acids as formyl peptide receptor like-1 (FPRL-1) receptor modulators FPR1, FPR3, FPR2 PAOX 2393/4885ALDH1A1 4424/4885SOAT1 3506/4885
US-10993931-B2 Amide derivatives of N-urea substituted amino acids as formyl peptide receptor like-1 (FPRL-1) receptor modulators FPR1, FPR3, FPR2 PAOX 2393/4885ALDH1A1 4424/4885SOAT1 3506/4885
US-20240285584-A1 AMIDE DERIVATIVES OF N-UREA SUBSTITUTED AMINO ACIDS AS FORMYL PEPTIDERECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS FPR1, FPR3, FPR2 PAOX 2011/4885ALDH1A1 4067/4885SOAT1 3194/4885
US-20110144033-A1 Proteasome Inhibitors and Methods of Using the Same PSMB11, PSMB5, PSMB6 PAOX 1819/4885ALDH1A1 3935/4885SOAT1 3753/4885
US-20220202777-A1 AMIDE DERIVATIVES OF N-UREA SUBSTITUTED AMINO ACIDS AS FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS FPR1, FPR3, FPR2 PAOX 2393/4885ALDH1A1 4424/4885SOAT1 3506/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.