⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene SCHEMBL9699905 | 0.96 | — | — | |
| Fumaric Acid SCHEMBL8866223 | 0.88 | DRD2 (0.46) | — | |
| Maleic Acid SCHEMBL8867832 | 0.88 | DRD2 (0.46) | — | |
| Fumaric Acid SCHEMBL8866214 | 0.88 | DRD2 (0.46) | — | |
| SCHEMBL19852102 | 0.82 | — | — | |
| SCHEMBL13363110 | 0.80 | — | — | |
| SCHEMBL5000310 | 0.78 | — | — | |
| SCHEMBL21802371 | 0.78 | — | — | |
| SCHEMBL678126 | 0.78 | — | — | |
| SCHEMBL4522775 | 0.77 | OPRM1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5594000-A | THAT STIMULATE CENTRAL MUSCARINIC ACETYLCHOLINE RECEPTORS, ANALGESICS, NERVOUS SYSTEM DISORDERS, MENTAL ILLNESS | ASTRA AB (SE) | 1997-01-14 | — | — | US | claimed |
| US-5075317-A | 2,8-dimethyl-1-oxa-8-azospiro(4.5) decan-3-one; alzheimer*s di sease | FISONS CORPORATION (US) | 1991-12-24 | — | — | US | claimed |
| EP-2389383-B1 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RES (IL) | 2019-04-24 | — | — | EP | disclosed |
| US-9034891-B2 | Bicyclic heterocyclic spiro compounds | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2015-05-19 | — | — | US | disclosed |
| US-8673931-B2 | Bicyclic heterocyclic spiro compounds | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2014-03-18 | — | — | US | disclosed |
| US-20130225624-A1 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2013-08-29 | — | — | US | disclosed |
| EP-2389383-A2 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2011-11-30 | — | — | EP | disclosed |
| US-20110281903-A1 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2011-11-17 | — | — | US | disclosed |
| US-8038638-B2 | Plasma detoxification and volume control system and methods of use | HEMOLIFE MEDICAL, INC. (US) | 2011-10-18 | — | — | US | disclosed |
| WO-2010084499-A9 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2010-12-09 | — | — | WO | disclosed |
| WO-2010084499-A2 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2010-07-29 | — | — | WO | disclosed |
| EP-0490901-A1 | NOVEL SPIROFURANE DERIVATIVES | Astra Aktiebolag (SE) | 1992-06-24 | — | — | EP | disclosed |
| EP-0491562-A1 | Novel spirofurane derivatives | FISONS CORPORATION (US) | 1992-06-24 | — | — | EP | disclosed |
| EP-0490901-A4 | NOVEL SPIROFURANE DERIVATIVES. | FISONS CORP (US) | 1992-04-13 | — | — | EP | disclosed |
| US-5075317-A | 2,8-dimethyl-1-oxa-8-azospiro(4.5) decan-3-one; alzheimer*s di sease | FISONS CORPORATION (US) | 1991-12-24 | — | — | US | disclosed |
| US-5041549-A | Cholinergin agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1991-08-20 | — | — | US | disclosed |
| US-4996210-A | Cognition activators, nervous system disorders; muscarinic acetylcholine receptor agonists; 2,8-dimethyl-3-methylene-1-oxa-8-azaspiro[4.5]decane for example | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1991-02-26 | — | — | US | disclosed |
| WO-1990015804-A1 | NOVEL SPIROFURANE DERIVATIVES | FISONS CORPORATION (US) | 1990-12-27 | — | — | WO | disclosed |
| US-4940795-A | Heterocyclic spiro compounds and methods for preparing the same | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1990-07-10 | — | — | US | disclosed |
| EP-0311313-A2 | Heterocyclic spiro compounds and their preparation | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1989-04-12 | — | — | EP | disclosed |