Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.62 |
| ▸ | AR | P10275 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL581787 | 0.83 | AR (0.70) | PARP1ARLMNACYP3A4CYP2C9 | |
| SCHEMBL12955544 | 0.78 | AR (0.77) | PARP1ARLMNACYP3A4CYP2C9 | |
| SCHEMBL12955526 | 0.78 | AR (0.77) | PARP1ARLMNACYP3A4CYP2C9 | |
| SCHEMBL863462 | 0.78 | AR (1.00) | PARP1ARLMNACYP3A4CYP2C9 | |
| SCHEMBL12955553 | 0.76 | PARP1 (0.76) | PARP1ARLMNACYP3A4CYP2C9 | |
| SCHEMBL24000626 | 0.76 | PARP1 (0.72) | PARP1ARLMNACYP3A4CYP2C9 | |
| SCHEMBL12955341 | 0.76 | AR (0.77) | PARP1ARLMNACYP3A4CYP2C9 | |
| SCHEMBL1789242 | 0.76 | LMNA (1.00) | PARP1ARLMNACYP3A4CYP2C9 | |
| SCHEMBL8154178 | 0.76 | AR (0.77) | PARP1ARLMNACYP3A4CYP2C9 | |
| SCHEMBL7122967 | 0.76 | AR (0.77) | PARP1ARLMNACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7750006-B2 | Phthalazinone derivatives | KUDOS PHARMACEUTICALS LIMITED (GB) | 2010-07-06 | — | — | US | disclosed |