Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | KMO | O15229 | 1/20 | 0.55 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24087489 | 0.98 | HDAC8 (0.56) | HDAC8HDAC6HDAC1KMOHAO1 | |
| SCHEMBL3495930 | 0.96 | HDAC8 (0.63) | HDAC8HDAC6HDAC1KMOHAO1 | |
| SCHEMBL354930 | 0.94 | KMO (0.62) | HDAC8HDAC6HDAC1KMOHAO1 | |
| SCHEMBL22291720 | 0.94 | KMO (0.62) | HDAC8HDAC6HDAC1KMOHAO1 | |
| SCHEMBL9471737 | 0.92 | CYP2D6 (0.50) | HDAC8HDAC6HDAC1KMOHAO1 | |
| Bicarbonate SCHEMBL7018415 | 0.92 | KMO (0.61) | HDAC8HDAC6HDAC1KMOHAO1 | |
| SCHEMBL2321634 | 0.91 | TSHR (0.57) | HDAC8HDAC6HDAC1KMOHAO1 | |
| SCHEMBL901207 | 0.91 | TSHR (0.57) | HDAC8HDAC6HDAC1KMOHAO1 | |
| SCHEMBL901209 | 0.91 | TSHR (0.57) | HDAC8HDAC6HDAC1KMOHAO1 | |
| SCHEMBL21656804 | 0.89 | PARP10 (0.53) | HDAC8HDAC6HDAC1KMOHAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190766-A1 | ANTIBACTERIAL AGENTS | ACHAOGEN, INC. (US) | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190766-A1 | ANTIBACTERIAL AGENTS | MRPL21, SI, ABCB11 | HDAC8 1902/4885HDAC6 552/4885HDAC1 702/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.