Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 2/20 | 0.60 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.60 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.60 |
| ▸ | AHCY | P23526 | 2/20 | 0.59 |
| ▸ | NADK | O95544 | 1/20 | 0.59 |
| ▸ | NT5E | P21589 | 1/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.58 |
| ▸ | P2RY1 | P47900 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.58 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.58 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.58 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.58 |
| ▸ | LDHA | P00338 | 1/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.58 |
| ▸ | FBP1 | P09467 | 1/20 | 0.58 |
| ▸ | SRC | P12931 | 1/20 | 0.58 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.58 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13268853 | 1.00 | PRKAG1 (0.60) | PRKAG1PRKAA1PRKAB1AHCYNADK | |
| SCHEMBL13268788 | 1.00 | PRKAG1 (0.60) | PRKAG1PRKAA1PRKAB1AHCYNADK | |
| SCHEMBL13269468 | 0.92 | AHCY (0.62) | PRKAG1PRKAA1PRKAB1AHCYNADK | |
| SCHEMBL13268675 | 0.91 | AHCY (0.61) | PRKAG1PRKAA1PRKAB1AHCYNADK | |
| SCHEMBL13268746 | 0.91 | AHCY (0.61) | PRKAG1PRKAA1PRKAB1AHCYNADK | |
| SCHEMBL13269136 | 0.91 | AHCY (0.61) | PRKAG1PRKAA1PRKAB1AHCYNADK | |
| SCHEMBL13268925 | 0.90 | AHCY (0.60) | PRKAG1PRKAA1PRKAB1AHCYNADK | |
| SCHEMBL13268772 | 0.90 | AHCY (0.60) | PRKAG1PRKAA1PRKAB1AHCYNADK | |
| SCHEMBL13268679 | 0.90 | AHCY (0.60) | PRKAG1PRKAA1PRKAB1AHCYNADK | |
| SCHEMBL13269107 | 0.90 | AHCY (0.60) | PRKAG1PRKAA1PRKAB1AHCYNADK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130045942-A1 | N6-SUBSTITUTED ADENOSINE DERIVATIVES AND N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2013-02-21 | — | — | US | claimed |
| EP-2511283-A1 | N6-SUBSTITUTED ADENOSINE DERIVATIVES, N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2012-10-17 | — | — | EP | claimed |
| US-10174033-B2 | N6-substituted adenosine derivatives and N6-substituted adenine derivatives and uses thereof | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2019-01-08 | — | — | US | disclosed |
| WO-2015176542-A1 | N6-(1-(4-METHOXYPHENYL)ETHYL)-ADENOSINE, PREPARATION AND USE THEREOF | 中国医学科学院药物研究所 | 2015-11-26 | — | — | WO | disclosed |
| CN-105085594-A | Preparation method and uses of N<6>-(1-(4-methoxyphenyl)ethyl)-adenosine | INST MATERIA MEDICA CAMS | 2015-11-25 | — | — | CN | disclosed |
| CN-105085594-A | Preparation method and uses of N<6>-(1-(4-methoxyphenyl)ethyl)-adenosine | INST MATERIA MEDICA CAMS | 2015-11-25 | — | — | CN | disclosed |
| CN-104382924-A | N6-substituted adenosine derivative and N6-substituted adenine derivative and application thereof | INST MATERIA MEDICA CAMS | 2015-03-04 | — | — | CN | disclosed |
| US-20130045942-A1 | N6-SUBSTITUTED ADENOSINE DERIVATIVES AND N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2013-02-21 | — | — | US | disclosed |
| EP-2511283-A1 | N6-SUBSTITUTED ADENOSINE DERIVATIVES, N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2012-10-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10174033-B2 | N6-substituted adenosine derivatives and N6-substituted adenine derivatives and uses thereof | ADORA2A, ADORA3, ADORA1 | PRKAG1 115/4885PRKAA1 341/4885PRKAB1 129/4885 |
| US-20130045942-A1 | N6-SUBSTITUTED ADENOSINE DERIVATIVES AND N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF | ADORA2A, ADORA3, ADORA1 | PRKAG1 115/4885PRKAA1 341/4885PRKAB1 129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.