Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICOSLG | O75144 | 11/20 | 0.40 |
| ▸ | ICOS | Q9Y6W8 | 11/20 | 0.40 |
| ▸ | CHUK | O15111 | 10/20 | 0.40 |
| ▸ | IKBKB | O14920 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | VCP | P55072 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1800497 | 0.72 | CHUK (0.52) | ICOSLGICOSCHUKIKBKBTYK2 | |
| SCHEMBL1797764 | 0.67 | ICOSLG (0.49) | ICOSLGICOSCHUKIKBKBTYK2 | |
| SCHEMBL8341671 | 0.65 | POLB (0.63) | MEN1KMT2AP2RX7KDM4ERXFP1 | |
| SCHEMBL14253072 | 0.62 | CHUK (0.74) | ICOSLGICOSCHUKIKBKBTYK2 | |
| SCHEMBL14050786 | 0.61 | TDP1 (0.77) | KMT2AP2RX7KDM4ERXFP1L3MBTL1 | |
| SCHEMBL27718071 | 0.59 | TDP1 (0.57) | MEN1KMT2AKDM4ERXFP1L3MBTL1 | |
| SCHEMBL25480675 | 0.59 | ICOSLG (0.66) | ICOSLGICOSCHUKIKBKBTYK2 | |
| SCHEMBL113365 | 0.59 | P2RX7 (1.00) | KMT2AP2RX7KDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL17225471 | 0.58 | CHUK (0.81) | ICOSLGICOSCHUKIKBKBTYK2 | |
| SCHEMBL11344287 | 0.58 | PRKCI (0.67) | TYK2MEN1KMT2AP2RX7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2206713-A1 | Beta-carbolines useful for treating inflammatory disease | Millennium Pharmaceuticals, Inc. (US) | 2010-07-14 | — | — | EP | disclosed |