Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICOSLG | O75144 | 4/20 | 0.66 |
| ▸ | ICOS | Q9Y6W8 | 4/20 | 0.66 |
| ▸ | CHUK | O15111 | 2/20 | 0.66 |
| ▸ | IKBKB | O14920 | 1/20 | 0.66 |
| ▸ | TYK2 | P29597 | 1/20 | 0.66 |
| ▸ | CLK1 | P49759 | 1/20 | 0.66 |
| ▸ | CLK2 | P49760 | 1/20 | 0.66 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.66 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.66 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | VCP | P55072 | 1/20 | 0.42 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17225471 | 0.90 | CHUK (0.81) | ICOSLGICOSCHUKIKBKBTYK2 | |
| SCHEMBL1802564 | 0.81 | CHUK (0.77) | ICOSLGICOSCHUKIKBKBTYK2 | |
| SCHEMBL30039188 | 0.80 | CHUK (1.00) | ICOSLGICOSCHUKIKBKBTYK2 | |
| SCHEMBL30492167 | 0.80 | CHUK (1.00) | ICOSLGICOSCHUKIKBKBTYK2 | |
| SCHEMBL1420073 | 0.80 | CHUK (1.00) | ICOSLGICOSCHUKIKBKBTYK2 | |
| SCHEMBL12619277 | 0.80 | CHUK (0.75) | ICOSLGICOSCHUKIKBKBTYK2 | |
| SCHEMBL1801454 | 0.80 | CHUK (0.75) | ICOSLGICOSCHUKIKBKBTYK2 | |
| SCHEMBL30342072 | 0.80 | CHUK (1.00) | ICOSLGICOSCHUKIKBKBTYK2 | |
| Hydrochloric Acid SCHEMBL18114522 | 0.79 | CHUK (0.98) | ICOSLGICOSCHUKIKBKBTYK2 | |
| SCHEMBL1798941 | 0.78 | CHUK (0.84) | ICOSLGICOSCHUKIKBKBTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230250085-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA | 2023-08-10 | — | — | US | disclosed |
| US-11661411-B2 | Quinoxaline compounds and uses thereof | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2023-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11661411-B2 | Quinoxaline compounds and uses thereof | NFKBIA, RELA, IKBKB | ICOSLG 4734/4885ICOS 4768/4885CHUK 4/4885 |
| US-20230250085-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | NFKBIA, RELA, IKBKB | ICOSLG 4734/4885ICOS 4768/4885CHUK 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.