SCHEMBL132841

SCHEMBL132841

COc1ccc(C(C)C)cc1OB(O)O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 1/20 0.44
PPARD Q03181 1/20 0.44
PPARA Q07869 1/20 0.44
CYP1A2 P05177 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
KMT2A Q03164 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
HDAC4 P56524 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
ACHE P22303 3/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
ERN1 O75460 1/20 0.40
BCHE P06276 1/20 0.39
ALDH1A1 P00352 4/20 0.38
HPGD P15428 1/20 0.38
LMNA P02545 1/20 0.38
TP53 P04637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL132840 0.85 HDAC4 (0.44) PPARGPPARDPPARACYP1A2CYP2C9
SCHEMBL84033 0.82 PPARG (0.53) PPARGPPARDPPARACYP1A2CYP2C9
SCHEMBL30581674 0.78 ENPP2 (0.48) PPARGPPARDPPARACYP1A2CYP2C9
SCHEMBL5410987 0.78 ENPP2 (0.48) PPARGPPARDPPARACYP1A2CYP2C9
SCHEMBL29957363 0.78 ENPP2 (0.48) PPARGPPARDPPARACYP1A2CYP2C9
SCHEMBL130864 0.78 ENPP2 (0.48) PPARGPPARDPPARACYP1A2CYP2C9
SCHEMBL4099192 0.76 CA12 (0.65) CYP1A2CYP2C9CYP2C19KMT2ANPSR1
SCHEMBL30523913 0.76 CA12 (0.65) CYP1A2CYP2C9CYP2C19KMT2ANPSR1
SCHEMBL11951618 0.76 ALDH1A1 (0.47) PPARGPPARDPPARACYP1A2CYP2C9
SCHEMBL4097559 0.74 NFE2L2 (0.44) CYP1A2CYP2C9CYP2C19KMT2ANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1979331-B1 TRISUBSTITUTED AMINE COMPOUNDS AS INHIBITORS OF -CHOLESTERYL ESTER TRANSFER PROTEIN CETP MITSUBISHI TANABE PHARMA CORP (JP) 2012-03-07 EP disclosed
EP-1979331-A1 TRISUBSTITUTED AMINE COMPOUNDS AS INHIBITORS OF -CHOLESTERYL ESTER TRANSFER PROTEIN CETP Mitsubishi Tanabe Pharma Corporation (JP) 2008-10-15 EP disclosed
WO-2007088996-A1 TRISUBSTITUTED AMINE COMPOUNDS AS INHIBITORS OF -CHOLESTERYL ESTER TRANSFER PROTEIN CETP MITSUBISHI TANABE PHARMA CORPORATION (JP) 2007-08-09 WO disclosed