Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | FPR3 | P25089 | 2/20 | 0.32 |
| ▸ | FPR2 | P25090 | 2/20 | 0.32 |
| ▸ | FPR1 | P21462 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1743885 | 1.00 | HDAC1 (0.35) | HDAC1ATMAAK1BACE1CYP1A2 | |
| SCHEMBL2547509 | 0.93 | ATM (0.36) | HDAC1ATMAAK1BACE1CYP1A2 | |
| SCHEMBL2547505 | 0.93 | ATM (0.36) | HDAC1ATMAAK1BACE1CYP1A2 | |
| SCHEMBL2550412 | 0.87 | MLYCD (0.39) | ATMAAK1FPR3FPR2 | |
| SCHEMBL13286149 | 0.84 | ATM (0.36) | ATMAAK1FPR3FPR2 | |
| SCHEMBL4303581 | 0.83 | PPARG (0.39) | ATMAAK1 | |
| SCHEMBL2550327 | 0.83 | ATM (0.38) | ATMAAK1 | |
| SCHEMBL2550321 | 0.83 | ATM (0.38) | ATMAAK1 | |
| SCHEMBL4303579 | 0.83 | PPARG (0.39) | ATMAAK1 | |
| SCHEMBL13286102 | 0.83 | DYRK1A (0.34) | HDAC1CYP1A2CYP2D6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083246-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2010-07-22 | — | — | WO | disclosed |