Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 8/20 | 0.34 |
| ▸ | GSK3B | P49841 | 5/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 5/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PTPRB | P23467 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12241747 | 1.00 | DYRK1A (0.34) | DYRK1AGSK3BPDPK1WNT1PTPN1 | |
| SCHEMBL2549038 | 0.94 | DYRK1A (0.34) | DYRK1AGSK3BPDPK1WNT1PTPN1 | |
| SCHEMBL2549043 | 0.94 | DYRK1A (0.34) | DYRK1AGSK3BPDPK1WNT1PTPN1 | |
| SCHEMBL1744901 | 0.87 | PTPRB (0.35) | DYRK1AGSK3BPDPK1WNT1PTPN1 | |
| SCHEMBL1743840 | 0.87 | AKT1 (0.40) | DYRK1AGSK3BPDPK1WNT1PTPN1 | |
| SCHEMBL2549583 | 0.86 | MLYCD (0.37) | DYRK1AGSK3BPDPK1WNT1PTPN1 | |
| SCHEMBL1743901 | 0.86 | GSK3B (0.33) | DYRK1AGSK3BPDPK1WNT1PTPN1 | |
| SCHEMBL12266678 | 0.86 | DYRK1A (0.33) | DYRK1AGSK3BPDPK1WNT1PTPN1 | |
| SCHEMBL1743885 | 0.83 | HDAC1 (0.35) | SMN1; SMN2CYP1A2CYP2D6HDAC1 | |
| SCHEMBL13286161 | 0.83 | HDAC1 (0.35) | SMN1; SMN2CYP1A2CYP2D6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083246-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2010-07-22 | — | — | WO | disclosed |