Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 1/20 | 0.68 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 6/20 | 0.41 |
| ▸ | PPARD | Q03181 | 6/20 | 0.41 |
| ▸ | PPARA | Q07869 | 6/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TLR2 | O60603 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | FABP4 | P15090 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26253430 | 0.84 | MEN1 (0.50) | PLA2G4APLA2G2AMEN1KMT2A | |
| SCHEMBL1877382 | 0.81 | PLA2G4A (1.00) | PLA2G4APLA2G2AEPHX2AKR1B1MEN1 | |
| SCHEMBL2770529 | 0.81 | PLA2G4A (1.00) | PLA2G4APLA2G2AEPHX2AKR1B1MEN1 | |
| SCHEMBL25783478 | 0.80 | PLA2G2A (0.53) | PLA2G4APLA2G2AEPHX2MEN1KMT2A | |
| SCHEMBL13286569 | 0.80 | TSHR (0.52) | PLA2G4APLA2G2AEPHX2TSHRALDH1A1 | |
| SCHEMBL13991907 | 0.80 | PLA2G4A (0.54) | PLA2G4APLA2G2AEPHX2MEN1KMT2A | |
| SCHEMBL1912627 | 0.78 | MEN1 (0.70) | PLA2G4APLA2G2AEPHX2ADRA1APRMT1 | |
| SCHEMBL13991893 | 0.78 | PLA2G4A (0.57) | PLA2G4APLA2G2AEPHX2MEN1KMT2A | |
| SCHEMBL28254961 | 0.78 | PLA2G4A (0.55) | PLA2G4APLA2G2AEPHX2ADRA1APRMT1 | |
| SCHEMBL28776220 | 0.77 | PLA2G2A (1.00) | PLA2G4APLA2G2AEPHX2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745489-B2 | Compositions and methods for inhibition of phospholipase A2 mediated inflammation | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-06-29 | — | — | US | disclosed |
| US-20080319065-A1 | Systemic and Intrathecal Effects of a Novel Series of Phospholipase A2 Inhibitors on Hyperalgesia and Spinal Pge2 Release | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080319065-A1 | Systemic and Intrathecal Effects of a Novel Series of Phospholipase A2 Inhibitors on Hyperalgesia and Spinal Pge2 Release | PLA2G4A, PLA2G4B, PLA2G2A | PLA2G4A 1/4885PLA2G2A 3/4885EPHX2 140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.