Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.86 |
| ▸ | HPGD | P15428 | 7/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.77 |
| ▸ | TSHR | P16473 | 4/20 | 0.77 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.77 |
| ▸ | POLB | P06746 | 4/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.77 |
| ▸ | MEN1 | O00255 | 3/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.77 |
| ▸ | RECQL | P46063 | 3/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.77 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.77 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.77 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.77 |
| ▸ | HTR2B | P41595 | 2/20 | 0.77 |
| ▸ | CASP7 | P55210 | 2/20 | 0.77 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14644982 | 0.92 | SIRT1 (1.00) | SIRT1HPGDHSD17B10TSHRHIF1A | |
| Hexachlorophene SCHEMBL29352805 | 0.88 | HSD17B10 (1.00) | SIRT1HPGDHSD17B10TSHRHIF1A | |
| Hexachlorophene SCHEMBL15579 | 0.88 | HSD17B10 (1.00) | SIRT1HPGDHSD17B10TSHRHIF1A | |
| SCHEMBL23543131 | 0.86 | SIRT1 (0.89) | SIRT1HPGDHSD17B10TSHRHIF1A | |
| Hexachlorophene SCHEMBL16339207 | 0.86 | HSD17B10 (0.95) | SIRT1HPGDHSD17B10TSHRHIF1A | |
| Hexachlorophene SCHEMBL2806744 | 0.86 | HSD17B10 (0.95) | SIRT1HPGDHSD17B10TSHRHIF1A | |
| Hexachlorophene SCHEMBL3468532 | 0.86 | HSD17B10 (0.95) | SIRT1HPGDHSD17B10TSHRHIF1A | |
| Hexachlorophene SCHEMBL2810158 | 0.86 | HSD17B10 (0.95) | SIRT1HPGDHSD17B10TSHRHIF1A | |
| Hexachlorophene SCHEMBL19689282 | 0.86 | HSD17B10 (0.95) | SIRT1HPGDHSD17B10TSHRHIF1A | |
| Hexachlorophene SCHEMBL11693520 | 0.86 | HSD17B10 (0.95) | SIRT1HPGDHSD17B10TSHRHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9527878-B2 | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-12-27 | — | — | US | disclosed |
| US-20160009748-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS AND METHODS OF USE THEREOF TO MODULATE LIPID METABOLISM | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-01-14 | — | — | US | disclosed |
| US-9120744-B2 | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-09-01 | — | — | US | disclosed |
| US-20100137194-A1 | Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137194-A1 | Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism | SERPINE1, PLAT, SERPINB1 | SIRT1 486/4885HPGD 502/4885HSD17B10 275/4885 |
| US-20160009748-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS AND METHODS OF USE THEREOF TO MODULATE LIPID METABOLISM | SERPINE1, PLAT, SERPINB1 | SIRT1 486/4885HPGD 502/4885HSD17B10 275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.