Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hexachlorophene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 9/20 | 1.00 |
| ▸ | HPGD | P15428 | 7/20 | 1.00 |
| ▸ | TSHR | P16473 | 7/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 4/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | RECQL | P46063 | 2/20 | 1.00 |
| ▸ | THRB | P10828 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 2/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | NPC1 | O15118 | 1/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | EGFR | P00533 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | ESR1 | P03372 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hexachlorophene SCHEMBL15579 | 1.00 | HSD17B10 (1.00) | HSD17B10HPGDTSHRCYP3A4HIF1A | |
| Hexachlorophene SCHEMBL2806744 | 0.98 | HSD17B10 (0.95) | HSD17B10HPGDTSHRCYP3A4HIF1A | |
| Hexachlorophene SCHEMBL3468532 | 0.98 | HSD17B10 (0.95) | HSD17B10HPGDTSHRCYP3A4HIF1A | |
| Hexachlorophene SCHEMBL19689282 | 0.98 | HSD17B10 (0.95) | HSD17B10HPGDTSHRCYP3A4HIF1A | |
| Hexachlorophene SCHEMBL16339207 | 0.98 | HSD17B10 (0.95) | HSD17B10HPGDTSHRCYP3A4HIF1A | |
| Hexachlorophene SCHEMBL11693520 | 0.98 | HSD17B10 (0.95) | HSD17B10HPGDTSHRCYP3A4HIF1A | |
| Hexachlorophene SCHEMBL2810158 | 0.98 | HSD17B10 (0.95) | HSD17B10HPGDTSHRCYP3A4HIF1A | |
| SCHEMBL13287028 | 0.88 | SIRT1 (0.86) | HSD17B10HPGDTSHRCYP3A4HIF1A | |
| SCHEMBL14644982 | 0.88 | SIRT1 (1.00) | HSD17B10HPGDTSHRCYP3A4HIF1A | |
| SCHEMBL8822888 | 0.87 | HSD17B10 (0.76) | HSD17B10HPGDTSHRCYP3A4HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1427 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12559452-B2 | Method for the synthesis of isocyanates | CYNIO GmbH (DE) | 2026-02-24 | — | — | US | claimed |
| EP-4300129-B1 | METHOD FOR CLUSTERING WAVEFORM DESCRIPTIONS | THALES SA (FR) | 2026-01-28 | — | — | EP | claimed |
| US-12516229-B2 | Printable silicone composition and methods for its preparation and use | DOW SILICONES CORPORATION (US) | 2026-01-06 | — | — | US | claimed |
| US-20250346592-A1 | HETEROCYCLIC PAD4 INHIBITORS | CELGENE CORPORATION | 2025-11-13 | — | — | US | claimed |
| EP-4628282-A2 | SYSTEM FOR MANUFACTURING A THERMOPLASTIC CONTAINER BY PULLING APART A TUBE | Valunorm BVBA (BE) | 2025-10-08 | — | — | EP | claimed |
| CN-120092036-A | Low temperature curable coating composition | 阿克苏诺贝尔涂料国际有限公司 | 2025-06-03 | — | — | CN | claimed |
| WO-2025108737-A1 | COSMETIC COMPOSITIONS COMPRISING A POLYMER AND A SURFACTANT | CLARIANT INTERNATIONAL LTD (CH) | 2025-05-30 | — | — | WO | claimed |
| CN-118656567-B | Method for calculating actual running emission total of light vehicle | 中汽研汽车检验中心(武汉)有限公司 | 2025-05-13 | — | — | CN | claimed |
| CN-119866865-A | Protective acquisition method of wild truffle | 云南省农业科学院生物技术与种质资源研究所 | 2025-04-25 | — | — | CN | claimed |
| US-12275798-B2 | Tri-specific binding molecules | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2025-04-15 | — | — | US | claimed |
| CN-114502539-A | Pharmaceutical compositions and combinations comprising inhibitors of androgen receptor and uses thereof | 埃萨制药股份有限公司 | 2022-05-13 | — | — | CN | claimed |
| CN-110911830-B | Passive frequency scanning Fabry-Perot resonant cavity antenna | 南京邮电大学 | 2022-04-26 | — | — | CN | claimed |
| CN-114350836-A | QTL qHD1b for promoting rice heading and application thereof | 中国水稻研究所 | 2022-04-15 | — | — | CN | claimed |
| CN-112280389-B | Mosquito-repellent interior wall coating added with Chinese herbal medicine extract and preparation method thereof | 三棵树(上海)新材料研究有限公司 | 2022-04-05 | — | — | CN | claimed |
| CN-114269331-A | Androgen receptor modulators and methods of use as proteolytic targeting chimeric ligands | 埃萨制药股份有限公司 | 2022-04-01 | — | — | CN | claimed |
| CN-112898955-B | High temperature high pressure oil-based mud system | 北京大德广源石油技术服务有限公司 | 2022-03-08 | — | — | CN | claimed |
| US-11255541-B2 | Joint seal system and method | THE SCHEBLER CO. (US) | 2022-02-22 | — | — | US | claimed |
| EP-3946292-A1 | ANDROGEN RECEPTOR MODULATORS AND METHODS FOR USE AS PROTEOLYSIS TARGETING CHIMERA LIGANDS | Essa Pharma, Inc. (CA) | 2022-02-09 | — | — | EP | claimed |
| EP-3947353-A1 | PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS COMPRISING INHIBITORS OF THE ANDROGEN RECEPTOR AND USES THEREOF | Essa Pharma, Inc. (CA) | 2022-02-09 | — | — | EP | claimed |
| US-20220024811-A1 | BONDING A GLASS-RESIN COMPOSITE MONOFILAMENT TO A THERMOPLASTIC MATRIX | COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) | 2022-01-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250346592-A1 | HETEROCYCLIC PAD4 INHIBITORS | PADI4, PADI6, PADI2 | HSD17B10 449/4885HPGD 409/4885TSHR 3442/4885 |
| US-12559452-B2 | Method for the synthesis of isocyanates | GCN1, SCN7A, GMNN | HSD17B10 1642/4885HPGD 2384/4885TSHR 2433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.