Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.51 |
| ▸ | GSK3B | P49841 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13288715 | 0.91 | ALDH1A1 (0.51) | CDK2GSK3BMEN1KMT2AHPGD | |
| SCHEMBL13119451 | 0.90 | CDK2 (0.65) | CDK2GSK3BPOLBMEN1KMT2A | |
| SCHEMBL14545834 | 0.89 | GSK3B (0.44) | CDK2GSK3BPOLBMEN1KMT2A | |
| SCHEMBL13288948 | 0.88 | BRD4 (0.45) | CDK2GSK3BMEN1KMT2AALDH1A1 | |
| SCHEMBL13288652 | 0.87 | CDK2 (0.51) | CDK2GSK3BMEN1KMT2AHPGD | |
| SCHEMBL13288676 | 0.86 | CDK2 (0.49) | CDK2GSK3BPOLBMEN1KMT2A | |
| SCHEMBL13119330 | 0.86 | CDK2 (0.61) | CDK2GSK3BPOLBMEN1KMT2A | |
| SCHEMBL13288866 | 0.85 | CDK2 (0.59) | CDK2GSK3BMEN1KMT2ARAB9A | |
| SCHEMBL13288769 | 0.84 | CDK2 (0.55) | CDK2GSK3BMEN1KMT2AHPGD | |
| SCHEMBL13288668 | 0.84 | CDK2 (0.55) | CDK2GSK3BMEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |