Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.46 |
| ▸ | GSK3B | P49841 | 3/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | SENP5 | Q96HI0 | 3/20 | 0.40 |
| ▸ | SENP2 | Q9HC62 | 3/20 | 0.40 |
| ▸ | SENP1 | Q9P0U3 | 3/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13119671 | 0.92 | CDK2 (0.57) | CDK2GSK3BMEN1KMT2A | |
| SCHEMBL13288712 | 0.90 | CDK2 (0.50) | CDK2GSK3BLOXL2MEN1KMT2A | |
| SCHEMBL13288878 | 0.89 | CDK2 (0.49) | CDK2GSK3BSIRT2SIRT3SENP5 | |
| SCHEMBL13288621 | 0.89 | CDK2 (0.46) | CDK2GSK3BSENP5SENP2SENP1 | |
| SCHEMBL13288889 | 0.89 | GSK3B (0.47) | CDK2GSK3BSENP5SENP2SENP1 | |
| SCHEMBL13288665 | 0.88 | CDK2 (0.46) | CDK2GSK3BMAPT | |
| SCHEMBL13288642 | 0.88 | CDK2 (0.49) | CDK2GSK3BSIRT2SENP1KDR | |
| SCHEMBL13289130 | 0.87 | RET (0.48) | CDK2GSK3BSENP5SENP2SENP1 | |
| SCHEMBL13119695 | 0.87 | CDK2 (0.58) | CDK2GSK3BSIRT2SIRT3KDR | |
| SCHEMBL13288729 | 0.86 | CDK2 (0.51) | CDK2GSK3BSENP5SENP2SENP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |