Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.47 |
| ▸ | CDK2 | P24941 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SENP5 | Q96HI0 | 1/20 | 0.37 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.37 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13119714 | 0.92 | CDK2 (0.58) | GSK3BCDK2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13289130 | 0.89 | RET (0.48) | GSK3BCDK2MEN1MAPTKMT2A | |
| SCHEMBL13288759 | 0.89 | CDK2 (0.46) | GSK3BCDK2SMN1; SMN2MEN1MAPT | |
| SCHEMBL13288878 | 0.88 | CDK2 (0.49) | GSK3BCDK2RAB9ANPC1MEN1 | |
| SCHEMBL13288665 | 0.87 | CDK2 (0.46) | GSK3BCDK2MAPT | |
| SCHEMBL13288642 | 0.87 | CDK2 (0.49) | GSK3BCDK2RETKDRSENP1 | |
| SCHEMBL13288729 | 0.86 | CDK2 (0.51) | GSK3BCDK2MEN1KMT2ASENP5 | |
| SCHEMBL13288880 | 0.86 | CDK2 (0.44) | GSK3BCDK2SMN1; SMN2MAPTRET | |
| SCHEMBL13289111 | 0.85 | CDK2 (0.52) | GSK3BCDK2KDR | |
| SCHEMBL13288663 | 0.85 | CDK2 (0.47) | GSK3BCDK2RAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |