Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13120125 | 0.91 | GSK3B (0.55) | MAPTALDH1A1GSK3BMEN1KMT2A | |
| SCHEMBL13120045 | 0.89 | GSK3B (0.55) | MAPTALDH1A1GSK3BMEN1KMT2A | |
| SCHEMBL13288955 | 0.86 | GSK3B (0.45) | MAPTALDH1A1GSK3BMEN1KMT2A | |
| SCHEMBL13120256 | 0.86 | GSK3B (0.57) | MAPTALDH1A1GSK3BMEN1KMT2A | |
| SCHEMBL13289193 | 0.82 | GSK3B (0.47) | MAPTALDH1A1GSK3BMEN1KMT2A | |
| SCHEMBL13289249 | 0.82 | GSK3B (0.46) | MAPTALDH1A1GSK3BMEN1KMT2A | |
| SCHEMBL13288841 | 0.81 | GSK3B (0.47) | MAPTALDH1A1GSK3BMEN1KMT2A | |
| SCHEMBL14545258 | 0.80 | GSK3B (0.46) | MAPTALDH1A1GSK3BMEN1KMT2A | |
| SCHEMBL13120380 | 0.80 | GSK3B (0.53) | MAPTGSK3BKDM4EPOLBCDK2 | |
| SCHEMBL13119471 | 0.79 | CDK2 (0.64) | GSK3BKDM4ECDK2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |