Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.46 |
| ▸ | CDK2 | P24941 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14561717 | 0.92 | GSK3B (0.57) | GSK3BCDK2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13120315 | 0.86 | GSK3B (0.59) | GSK3BCDK2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13288874 | 0.85 | GSK3B (0.46) | GSK3BCDK2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13289193 | 0.83 | GSK3B (0.47) | GSK3BCDK2SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL13288841 | 0.83 | GSK3B (0.47) | GSK3BCDK2ALDH1A1KDM4EMEN1 | |
| SCHEMBL13288739 | 0.83 | HPGD (0.48) | GSK3BCDK2ALDH1A1HPGD | |
| SCHEMBL14545258 | 0.82 | GSK3B (0.46) | GSK3BCDK2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13288688 | 0.82 | MAPT (0.45) | GSK3BCDK2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL13288955 | 0.81 | GSK3B (0.45) | GSK3BCDK2ALDH1A1MEN1KMT2A | |
| SCHEMBL13288943 | 0.80 | BRD4 (0.44) | GSK3BCDK2RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |