Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 5/20 | 0.50 |
| ▸ | GSK3B | P49841 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | LOX | P28300 | 2/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13119514 | 0.91 | CDK2 (0.63) | CDK2GSK3B | |
| SCHEMBL12953801 | 0.91 | CDK2 (0.50) | CDK2GSK3BSMN1; SMN2LMNAHTT | |
| SCHEMBL13288759 | 0.90 | CDK2 (0.46) | CDK2GSK3BSMN1; SMN2LMNALOXL2 | |
| SCHEMBL13288882 | 0.88 | CDK2 (0.54) | CDK2GSK3BPDE2APDE10A | |
| SCHEMBL13288715 | 0.88 | ALDH1A1 (0.51) | CDK2GSK3BHTTMAPK14KMT2A | |
| SCHEMBL13119412 | 0.87 | CDK2 (0.60) | CDK2GSK3B | |
| SCHEMBL13288768 | 0.86 | CDK2 (0.54) | CDK2GSK3BSMN1; SMN2MMP13KMT2A | |
| SCHEMBL13288769 | 0.86 | CDK2 (0.55) | CDK2GSK3BPDE2APDE10AKMT2A | |
| SCHEMBL13288668 | 0.86 | CDK2 (0.55) | CDK2GSK3BSMN1; SMN2PDE2APDE10A | |
| SCHEMBL13119595 | 0.85 | CDK2 (0.61) | CDK2GSK3BKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |