Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.42 |
| ▸ | GSK3B | P49841 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 7/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | VCP | P55072 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13120275 | 0.90 | CDK2 (0.54) | CDK2GSK3BSMN1; SMN2MEN1KMT2A | |
| SCHEMBL13288778 | 0.90 | CDK2 (0.49) | CDK2GSK3BSMN1; SMN2MEN1KMT2A | |
| SCHEMBL13288867 | 0.87 | CDK2 (0.47) | CDK2GSK3BABL1VCP | |
| SCHEMBL13120066 | 0.86 | CDK2 (0.52) | CDK2GSK3BSMN1; SMN2MEN1KMT2A | |
| SCHEMBL14545262 | 0.85 | CDK2 (0.45) | CDK2GSK3BSMN1; SMN2MEN1KMT2A | |
| SCHEMBL13288877 | 0.83 | CDK2 (0.45) | CDK2GSK3BABL1 | |
| SCHEMBL12954447 | 0.82 | CDK2 (0.46) | CDK2GSK3BABL1VCP | |
| SCHEMBL13288683 | 0.82 | CDK2 (0.46) | CDK2GSK3BABL1VCP | |
| SCHEMBL14613481 | 0.82 | SMN1; SMN2 (0.42) | CDK2GSK3BSMN1; SMN2MEN1KMT2A | |
| SCHEMBL13288970 | 0.81 | CDK2 (0.45) | CDK2GSK3BABL1VCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |