Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.46 |
| ▸ | GSK3B | P49841 | 7/20 | 0.46 |
| ▸ | AQP1 | P29972 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13120646 | 0.91 | CDK2 (0.57) | CDK2GSK3BCCNA2CCNA1 | |
| SCHEMBL13288974 | 0.89 | CDK2 (0.52) | CDK2GSK3BMEN1KMT2ACCNA2 | |
| SCHEMBL13288959 | 0.89 | CDK2 (0.43) | CDK2GSK3BMEN1KMT2ACCNA2 | |
| SCHEMBL13289430 | 0.88 | GSK3B (0.49) | CDK2GSK3BMEN1KMT2ACCNA2 | |
| SCHEMBL13289007 | 0.87 | GSK3B (0.41) | CDK2GSK3BMAPTCA12CA9 | |
| SCHEMBL13289440 | 0.86 | CDK2 (0.51) | CDK2GSK3BCCNA2CCNA1MAPT | |
| SCHEMBL13288964 | 0.85 | ALDH1A1 (0.48) | CDK2GSK3BMEN1KMT2A | |
| SCHEMBL12954278 | 0.84 | CDK2 (0.52) | CDK2GSK3BMEN1KMT2ACCNA2 | |
| SCHEMBL13289375 | 0.84 | CDK2 (0.54) | CDK2GSK3BMEN1KMT2ACCNA2 | |
| SCHEMBL13288977 | 0.84 | CDK2 (0.47) | CDK2GSK3BMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |