Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.46 |
| ▸ | CDK2 | P24941 | 4/20 | 0.46 |
| ▸ | KDR | P35968 | 5/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13120774 | 0.91 | CDK2 (0.57) | GSK3BCDK2KDRRETGAA | |
| SCHEMBL13288977 | 0.91 | CDK2 (0.47) | GSK3BCDK2GAANAMPTALDH1A1 | |
| SCHEMBL13288956 | 0.88 | CDK2 (0.48) | GSK3BCDK2KDRRETNAMPT | |
| SCHEMBL13289444 | 0.88 | CDK2 (0.49) | GSK3BCDK2KDRRETNAMPT | |
| SCHEMBL13288985 | 0.86 | CDK2 (0.48) | GSK3BCDK2KDRRETALDH1A1 | |
| SCHEMBL13289304 | 0.86 | CDK2 (0.48) | GSK3BCDK2KDRRETGAA | |
| SCHEMBL13289239 | 0.86 | GSK3B (0.51) | GSK3BCDK2KDRRETMEN1 | |
| SCHEMBL13289093 | 0.85 | CDK2 (0.48) | GSK3BCDK2ALDH1A1MEN1KMT2A | |
| SCHEMBL13289274 | 0.85 | GSK3B (0.46) | GSK3BCDK2GAAALPLALDH1A1 | |
| SCHEMBL13120722 | 0.84 | CDK2 (0.61) | GSK3BCDK2ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |