Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 5/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13288811 | 0.95 | CDK2 (0.44) | CDK2HIF1AGSK3BSMN1; SMN2DRD2 | |
| SCHEMBL13120304 | 0.89 | CDK2 (0.58) | CDK2HIF1AGSK3BCCNE1 | |
| SCHEMBL14545970 | 0.89 | GSK3B (0.45) | CDK2GSK3BDRD2DRD4DRD3 | |
| SCHEMBL13288895 | 0.89 | GSK3B (0.43) | CDK2GSK3BSMN1; SMN2MEN1LMNA | |
| SCHEMBL13288768 | 0.89 | CDK2 (0.54) | CDK2GSK3BSMN1; SMN2MEN1KMT2A | |
| SCHEMBL13289235 | 0.88 | CDK2 (0.45) | CDK2GSK3BDRD2DRD4DRD3 | |
| SCHEMBL14545832 | 0.87 | CDK2 (0.48) | CDK2GSK3BSMN1; SMN2LMNANPC1 | |
| SCHEMBL14545261 | 0.87 | CDK2 (0.53) | CDK2GSK3BSMN1; SMN2MEN1LMNA | |
| SCHEMBL13288902 | 0.86 | CDK2 (0.41) | CDK2GSK3BNAMPT | |
| SCHEMBL13288868 | 0.86 | CDK2 (0.52) | CDK2GSK3BNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |