Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.47 |
| ▸ | GSK3B | P49841 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13121785 | 0.93 | CDK2 (0.57) | CDK2GSK3BMEN1KMT2ARET | |
| SCHEMBL13289254 | 0.92 | CDK2 (0.47) | CDK2GSK3BMEN1KMT2ARET | |
| SCHEMBL13289345 | 0.92 | GSK3B (0.47) | CDK2GSK3BMEN1KMT2ARET | |
| SCHEMBL13289304 | 0.91 | CDK2 (0.48) | CDK2GSK3BMEN1KMT2ARET | |
| SCHEMBL13289534 | 0.90 | RET (0.48) | CDK2GSK3BRETKDRTP53 | |
| SCHEMBL13289563 | 0.88 | CDK2 (0.50) | CDK2GSK3BMEN1KMT2AKDR | |
| SCHEMBL13289245 | 0.88 | CDK2 (0.49) | CDK2GSK3BMEN1KMT2ARET | |
| SCHEMBL12954205 | 0.88 | CDK2 (0.49) | CDK2GSK3BRETKDR | |
| SCHEMBL14301776 | 0.87 | CDK2 (0.51) | CDK2GSK3BRETKDR | |
| SCHEMBL12954468 | 0.87 | CDK2 (0.51) | CDK2GSK3BMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |