Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.56 |
| ▸ | GSK3B | P49841 | 5/20 | 0.51 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 3/20 | 0.40 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.38 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14301776 | 0.93 | CDK2 (0.51) | CDK2GSK3BEPHB4CNR1 | |
| SCHEMBL13121694 | 0.90 | CDK2 (0.70) | CDK2GSK3B | |
| SCHEMBL14545901 | 0.90 | CDK2 (0.55) | CDK2GSK3BEPHB4PSDCNR1 | |
| SCHEMBL13288668 | 0.89 | CDK2 (0.55) | CDK2GSK3BNAMPTMEN1KMT2A | |
| SCHEMBL13121616 | 0.87 | CDK2 (0.68) | CDK2GSK3BNAMPTPSD | |
| SCHEMBL13289245 | 0.87 | CDK2 (0.49) | CDK2GSK3BEPHB4KCNJ6KCNJ5 | |
| SCHEMBL12954120 | 0.87 | CDK2 (0.49) | CDK2GSK3BEPHB4KCNJ6KCNJ5 | |
| SCHEMBL13288866 | 0.86 | CDK2 (0.59) | CDK2GSK3BMEN1KMT2A | |
| SCHEMBL12954468 | 0.86 | CDK2 (0.51) | CDK2GSK3BEPHB4MAPTMEN1 | |
| SCHEMBL14301775 | 0.86 | CDK2 (0.49) | CDK2GSK3BNAMPTKCNJ6KCNJ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |