SCHEMBL13291

SCHEMBL13291

O=C(O)c1cc2c(-n3cc(CCO)nn3)cccc2n1O

nearest known ligand 0.67

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
LDHA P00338 4/20 0.67
NOTUM Q6P988 8/20 0.44
MAOA P21397 1/20 0.41
MAOB P27338 1/20 0.41
DAO P14920 1/20 0.39
DDX3X O00571 1/20 0.37
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA4 P22748 1/20 0.35
CA7 P43166 1/20 0.35
CA9 Q16790 1/20 0.35
HDAC8 Q9BY41 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14118352 0.88 LDHA (0.63) LDHANOTUMMAOAMAOBDDX3X
SCHEMBL8027 0.80 LDHA (1.00) LDHADAOCA1CA2CA9
SCHEMBL7734 0.77 LDHA (1.00) LDHAMAOAMAOBCA1CA2
SCHEMBL14118941 0.75 LDHA (0.69) LDHANOTUMMAOAMAOBDAO
SCHEMBL8428 0.75 LDHA (0.84) LDHANOTUMMAOAMAOBDAO
SCHEMBL27867431 0.71 NOTUM (0.40) LDHANOTUMMAOAMAOBDDX3X
SCHEMBL16401559 0.66 NOTUM (0.74) NOTUMMAOADDX3XCA1CA2
SCHEMBL8014 0.66 DAO (0.56) LDHAMAOAMAOBDAOHDAC8
SCHEMBL14836547 0.65 NOTUM (0.48) LDHANOTUMMAOAMAOBDDX3X
SCHEMBL8055 0.65 DAO (0.54) LDHADAOHDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2499114-A1 COMPOUNDS INHIBITORS OF ENZYME LACTATE DEHYDROGENASE (LDH) AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS Universita Di Pisa (IT) 2012-09-19 EP disclosed
WO-2011054525-A1 COMPOUNDS INHIBITORS OF ENZYME LACTATE DEHYDROGENASE (LDH) AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS UNIVERSITA' DI PISA (IT) 2011-05-12 WO disclosed