Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.73 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.73 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.56 |
| ▸ | RECQL | P46063 | 3/20 | 0.56 |
| ▸ | THPO | P40225 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | ESR1 | P03372 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | IGF1R | P08069 | 2/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5164953 | 0.86 | GABRA1 (0.73) | GABRA1GABRB2ALOX15KDM4EALDH1A1 | |
| SCHEMBL318750 | 0.85 | GABRA1 (1.00) | GABRA1GABRB2ALOX15KDM4EALDH1A1 | |
| SCHEMBL7922257 | 0.83 | GABRA1 (0.81) | GABRA1GABRB2ALOX15KDM4EALDH1A1 | |
| SCHEMBL5164394 | 0.83 | GABRA1 (0.69) | GABRA1GABRB2ALOX15KDM4EALDH1A1 | |
| SCHEMBL5167205 | 0.81 | GABRA1 (0.79) | GABRA1GABRB2ALOX15KDM4EALDH1A1 | |
| SCHEMBL57083 | 0.81 | ALOX15 (0.76) | GABRA1GABRB2ALOX15KDM4EALDH1A1 | |
| SCHEMBL5342731 | 0.80 | GABRA1 (0.65) | GABRA1GABRB2ALOX15KDM4EALDH1A1 | |
| SCHEMBL28916258 | 0.80 | GABRA1 (0.89) | GABRA1GABRB2ALOX15KDM4EALDH1A1 | |
| SCHEMBL107956 | 0.78 | ALOX15 (0.80) | ALOX15KDM4EALDH1A1TP53MAPK1 | |
| SCHEMBL30631592 | 0.78 | ALOX15 (0.80) | ALOX15KDM4EALDH1A1TP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745490-B2 | Substituted N-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies | PROTEOTECH, INC. (US) | 2010-06-29 | — | — | US | disclosed |
| US-20090060838-A1 | SUBSTITUTED N-ARYL BENZAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES | PROTEOTECH INC. | 2009-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090060838-A1 | SUBSTITUTED N-ARYL BENZAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES | IAPP, SNCA, BACE2 | GABRA1 1300/4885GABRB2 354/4885ALOX15 4373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.