Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | DGKA | P23743 | 2/20 | 0.44 |
| ▸ | DGKG | P49619 | 1/20 | 0.44 |
| ▸ | DGKB | Q9Y6T7 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | CCR6 | P51684 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.43 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14489523 | 0.93 | KCNA5 (0.44) | DCTPP1ALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL13294772 | 0.90 | DCTPP1 (0.47) | DCTPP1ALDH1A1SMN1; SMN2DGKADGKG | |
| SCHEMBL3152870 | 0.88 | DGKA (0.57) | DCTPP1ALDH1A1SMN1; SMN2DGKADGKG | |
| SCHEMBL14489528 | 0.87 | DCTPP1 (0.42) | DCTPP1ALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL13294833 | 0.87 | DCTPP1 (0.42) | DCTPP1ALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL13294830 | 0.85 | SMN1; SMN2 (0.48) | DCTPP1ALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL13294832 | 0.85 | DCTPP1 (0.41) | DCTPP1ALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL13294693 | 0.85 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2DGKADGKGDGKB | |
| SCHEMBL13294720 | 0.83 | GAA (0.46) | DCTPP1ALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL5530007 | 0.83 | KCNA5 (0.44) | DCTPP1ALDH1A1SMN1; SMN2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7732146-B2 | Method for screening an agent that modulates activity of macrophage migration inhibitory factor | AVANIR PHARMACEUTICALS (US) | 2010-06-08 | — | — | US | disclosed |
| US-7732146-B2 | Method for screening an agent that modulates activity of macrophage migration inhibitory factor | AVANIR PHARMACEUTICALS (US) | 2010-06-08 | — | — | US | disclosed |
| EP-1389110-B1 | INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR AND METHODS FOR IDENTIFYING THE SAME | AVANIR PHARMACEUTICALS (US) | 2010-03-24 | — | — | EP | disclosed |
| US-7514225-B2 | Method for screening an agent that modulates activity of macrophage migration inhibitory factor | AVANIR PHARMACEUTICALS (US) | 2009-04-07 | — | — | US | disclosed |
| US-7435737-B2 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same | AVANIR PHARMACEUTIALS (US) | 2008-10-14 | — | — | US | disclosed |
| US-20070232613-A1 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same | AVANIR PHARMACEUTICALS | 2007-10-04 | — | — | US | disclosed |
| US-20070197547-A1 | INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR AND METHODS FOR IDENTIFYING THE SAME | AVANIR PHARMACEUTICALS (US) | 2007-08-23 | — | — | US | disclosed |
| US-7238809-B2 | Process for the preparation of inhibitors of macrophage migration inhibitory factor | AVANIR PHARMACEUTICALS (US) | 2007-07-03 | — | — | US | disclosed |
| US-7235565-B2 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same | AVANIR PHARMACEUTICALS (US) | 2007-06-26 | — | — | US | disclosed |
| US-7230106-B2 | Process for the preparation of inhibitors of macrophage migration inhibitory factor | AVANIR PHARMACEUTICALS (US) | 2007-06-12 | — | — | US | disclosed |
| US-7202248-B2 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same | AVANIR PHARMACEUTICALS (US) | 2007-04-10 | — | — | US | disclosed |
| US-7192955-B2 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same | AVANIR PHARMACEUTICALS (US) | 2007-03-20 | — | — | US | disclosed |
| US-7192961-B2 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same | AVANIR PHARMACEUTICALS (US) | 2007-03-20 | — | — | US | disclosed |
| US-20070021440-A1 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same | AVANIR PHARMACEUTICALS | 2007-01-25 | — | — | US | disclosed |
| US-7157469-B2 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same | AVANIR PHARMACEUTICALS (US) | 2007-01-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232613-A1 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same | MIF, MSR1, MMP12 | DCTPP1 4311/4885ALDH1A1 2081/4885SMN1; SMN2 4132/4885 |
| US-20070021440-A1 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same | MIF, MSR1, MMP12 | DCTPP1 4311/4885ALDH1A1 2081/4885SMN1; SMN2 4132/4885 |
| US-20070197547-A1 | INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR AND METHODS FOR IDENTIFYING THE SAME | MIF, MSR1, MMP12 | DCTPP1 4311/4885ALDH1A1 2081/4885SMN1; SMN2 4132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.