Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.54 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.50 |
| ▸ | CTSD | P07339 | 2/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30609958 | 0.96 | BACE1 (0.51) | BACE1BACE2CTSDMMP2 | |
| SCHEMBL30609969 | 0.96 | BACE1 (0.51) | BACE1BACE2CTSDMMP2 | |
| SCHEMBL30799335 | 0.94 | MMP2 (0.55) | BACE1CTSDMMP2 | |
| SCHEMBL30118074 | 0.93 | MMP2 (0.56) | BACE1BACE2CTSDMMP2 | |
| SCHEMBL31181273 | 0.92 | BACE1 (0.54) | BACE1BACE2 | |
| SCHEMBL31018950 | 0.92 | MMP2 (0.57) | BACE1BACE2CTSDMMP2 | |
| SCHEMBL31730257 | 0.90 | BACE1 (0.61) | BACE1CTSDMMP2 | |
| SCHEMBL31554972 | 0.90 | MMP2 (0.56) | BACE1MMP2 | |
| SCHEMBL30497073 | 0.90 | MMP2 (0.56) | BACE1MMP2 | |
| SCHEMBL30974003 | 0.90 | MMP2 (0.58) | BACE1BACE2CTSDMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737293-B2 | Amide forming chemical ligation | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-06-15 | — | — | US | disclosed |
| US-7737293-B2 | Amide forming chemical ligation | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-06-15 | — | — | US | disclosed |
| US-7667076-B2 | Amide forming chemical ligation | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-02-23 | — | — | US | disclosed |
| US-7667076-B2 | Amide forming chemical ligation | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-02-23 | — | — | US | disclosed |
| US-20090069536-A1 | Amide Forming Chemical Ligation | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2009-03-12 | — | — | US | disclosed |
| US-20090069536-A1 | Amide Forming Chemical Ligation | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2009-03-12 | — | — | US | disclosed |
| US-20070060773-A1 | Amide forming chemical ligation | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2007-03-15 | — | — | US | disclosed |
| US-20070060773-A1 | Amide forming chemical ligation | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069536-A1 | Amide Forming Chemical Ligation | CPS1, GLUL, PCCA | BACE1 4312/4885BACE2 4606/4885CTSD 2996/4885 |
| US-20070060773-A1 | Amide forming chemical ligation | CPS1, GLUL, PCCA | BACE1 4312/4885BACE2 4606/4885CTSD 2996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.