Octane

Octane

SCHEMBL1329752

CCCCCCCC.CCCCCCCC.CCCCCCCCCCCCCCCCC([SiH3])CCCCCCC

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.50
THRB P10828 1/20 0.50
LMNA P02545 1/20 0.48
DNM1 Q05193 2/20 0.48
OPRM1 P35372 1/20 0.46
GPR84 Q9NQS5 3/20 0.42
FDPS P14324 3/20 0.42
SPHK1 Q9NYA1 1/20 0.42
FFAR1 O14842 1/20 0.42
MAPT P10636 1/20 0.41
LCK P06239 1/20 0.41
PPARD Q03181 1/20 0.41
ZDHHC20 Q5W0Z9 1/20 0.41
ZDHHC2 Q9UIJ5 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL527218 1.00 TSHR (0.50) TSHRTHRBLMNADNM1OPRM1
SCHEMBL181209 1.00 TSHR (0.50) TSHRTHRBLMNADNM1OPRM1
SCHEMBL10803629 1.00 TSHR (0.50) TSHRTHRBLMNADNM1OPRM1
SCHEMBL7451309 1.00 TSHR (0.50) TSHRTHRBLMNADNM1OPRM1
SCHEMBL10843071 1.00 TSHR (0.50) TSHRTHRBLMNADNM1OPRM1
SCHEMBL6246199 1.00 TSHR (0.50) TSHRTHRBLMNADNM1OPRM1
SCHEMBL9342830 1.00 TSHR (0.50) TSHRTHRBLMNADNM1OPRM1
SCHEMBL9206465 1.00 TSHR (0.50) TSHRTHRBLMNADNM1OPRM1
SCHEMBL16209852 1.00 TSHR (0.50) TSHRTHRBLMNADNM1OPRM1
SCHEMBL10841356 1.00 TSHR (0.50) TSHRTHRBLMNADNM1OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10093757-B2 Silanol condensation catalysts for the cross-linking of filled and unfilled polymer compounds EVONIK DEGUSSA GMBH (DE) 2018-10-09 US disclosed
US-20130253144-A1 SILANOL CONDENSATION CATALYSTS FOR THE CROSS-LINKING OF FILLED AND UNFILLED POLYMER COMPOUNDS EVONIK DEGUSSA GMBH (DE) 2013-09-26 US disclosed
EP-2465897-B1 Master kit containing silanol condensation catalysts for integrating filled and unfilled polymer compounds EVONIK DEGUSSA GMBH (DE) 2012-12-26 EP disclosed
EP-2465897-A1 Master kit containing silanol condensation catalysts for integrating filled and unfilled polymer compounds Evonik Degussa GmbH (DE) 2012-06-20 EP disclosed
US-20110282024-A1 CATALYSTS FOR THE CROSS-LINKING OF FUNCTIONAL SILANES OR FUNCTIONAL SILOXANES, PARTICULARLY WITH SUBSTRATES EVONIK DEGUSSA GMBH (DE) 2011-11-17 US disclosed
US-20110144278-A1 SILANOL CONDENSATION CATALYSTS FOR THE CROSS-LINKING OF FILLED AND UNFILLED POLYMER COMPOUNDS EVONIK DEGUSSA GMBH (DE) 2011-06-16 US disclosed
US-20110144277-A1 USE OF SILICON-CONTAINING PRECURSOR COMPOUNDS OF AN ORGANIC ACID AS A CATALYST FOR CROSS-LINKING FILLED AND UNFILLED POLYMER COMPOUNDS EVONIK DEGUSSA GMBH (DE) 2011-06-16 US disclosed
EP-2331627-A1 USE OF SILICON-CONTAINING PRECURSOR COMPOUNDS OF AN ORGANIC ACID AS A CATALYST FOR CROSS-LINKING FILLED AND UNFILLED POLYMER COMPOUNDS Evonik Degussa GmbH (DE) 2011-06-15 EP disclosed
EP-2331622-A1 NEW CATALYSTS FOR THE CROSS-LINKING OF FUNCTIONAL SILANES OR FUNCTIONAL SILOXANES, PARTICULARLY WITH SUBSTRATES Evonik Degussa GmbH (DE) 2011-06-15 EP disclosed
WO-2010028877-A1 NEW CATALYSTS FOR THE CROSS-LINKING OF FUNCTIONAL SILANES OR FUNCTIONAL SILOXANES, PARTICULARLY WITH SUBSTRATES EVONIK DEGUSSA GMBH (DE) 2010-03-18 WO disclosed
WO-2010028875-A1 USE OF SILICON-CONTAINING PRECURSOR COMPOUNDS OF AN ORGANIC ACID AS A CATALYST FOR CROSS-LINKING FILLED AND UNFILLED POLYMER COMPOUNDS EVONIK DEGUSSA GMBH (DE) 2010-03-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110282024-A1 CATALYSTS FOR THE CROSS-LINKING OF FUNCTIONAL SILANES OR FUNCTIONAL SILOXANES, PARTICULARLY WITH SUBSTRATES SI, FOXO1, F11 TSHR 3535/4885THRB 4135/4885LMNA 1042/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.