Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.59 |
| ▸ | MAPT | P10636 | 8/20 | 0.59 |
| ▸ | POLB | P06746 | 5/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | PLEC | Q15149 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12305614 | 0.91 | MAPT (0.58) | MEN1KMT2AMAPTPOLBHTT | |
| SCHEMBL12830486 | 0.89 | MEN1 (0.55) | MEN1KMT2AMAPTPOLBHTT | |
| SCHEMBL12305594 | 0.87 | MAPT (0.49) | MEN1KMT2AMAPTPOLBHTT | |
| SCHEMBL11665696 | 0.83 | MAPT (0.55) | MEN1KMT2AMAPTPOLBHTT | |
| SCHEMBL5158239 | 0.81 | MAPT (0.59) | MEN1KMT2AMAPTPOLBHTT | |
| SCHEMBL12305611 | 0.78 | MEN1 (0.67) | MEN1KMT2AMAPTPOLBHTT | |
| SCHEMBL24891375 | 0.75 | MAPT (0.58) | MEN1KMT2AMAPTPOLBHTT | |
| SCHEMBL11598756 | 0.73 | ALDH1A1 (0.55) | MEN1KMT2AMAPTPOLBRAB9A | |
| SCHEMBL14565052 | 0.73 | NQO2 (0.54) | MEN1KMT2AMAPTPOLBHTT | |
| SCHEMBL92063 | 0.73 | MAPT (0.52) | MEN1KMT2AMAPTPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091974-B1 | CAVITY INDUCED ALLOSTERIC MODIFICATION OF INTERMOLECULAR INTERACTIONS AND METHODS OF IDENTIFYING COMPOUNDS THAT EFFECT THE SAME | UNIV PENNSYLVANIA (US) | 2010-06-02 | — | — | EP | disclosed |