Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | MTHFD1 | P11586 | 3/20 | 0.53 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.51 |
| ▸ | FPGS | Q05932 | 2/20 | 0.50 |
| ▸ | MTHFD2 | P13995 | 3/20 | 0.45 |
| ▸ | ATIC | P31939 | 3/20 | 0.44 |
| ▸ | TYMS | P04818 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13477849 | 1.00 | DHFR (0.70) | DHFRLMNAMTHFD1SOSTFPGS | |
| Leucovorin SCHEMBL4708750 | 0.94 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTFPGS | |
| Leucovorin SCHEMBL8349 | 0.94 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTFPGS | |
| Levoleucovorin SCHEMBL571901 | 0.94 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTFPGS | |
| Folinic Acid SCHEMBL29369091 | 0.94 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTFPGS | |
| Leucovorin SCHEMBL8350 | 0.94 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTFPGS | |
| Leucovorin SCHEMBL571902 | 0.94 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTFPGS | |
| Leucovorin SCHEMBL5132046 | 0.94 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTFPGS | |
| Leucovorin SCHEMBL21632556 | 0.94 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTFPGS | |
| Leucovorin SCHEMBL9054117 | 0.93 | DHFR (0.78) | DHFRLMNAMTHFD1SOSTFPGS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100143340-A1 | METHODS AND COMPOSITIONS FOR TREATING CANCER | SCHERING CORPORATION | 2010-06-10 | — | — | US | disclosed |
| US-20080090242-A1 | PANEL OF BIOMARKERS FOR PREDICTION OF FTI EFFICACY | SCHERING CORPORATION | 2008-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100143340-A1 | METHODS AND COMPOSITIONS FOR TREATING CANCER | TP53, KLK3, CD44 | DHFR 208/4885LMNA 1836/4885MTHFD1 1100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.