Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 3/20 | 0.44 |
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13301204 | 0.82 | SYK (0.50) | GSK3AGSK3BCDK5SYKADORA3 | |
| SCHEMBL13301199 | 0.81 | IRAK4 (0.51) | GSK3AGSK3BCDK5SYKADORA3 | |
| SCHEMBL7106970 | 0.79 | SYK (0.50) | MEN1KMT2ASYKADORA3ADORA2A | |
| SCHEMBL7104515 | 0.78 | ADORA3 (0.64) | MEN1KMT2ABLMGSK3AGSK3B | |
| SCHEMBL31061104 | 0.77 | ADORA3 (0.69) | MEN1KMT2ABLMGSK3AGSK3B | |
| SCHEMBL21601504 | 0.77 | ADORA3 (0.69) | MEN1KMT2ABLMGSK3AGSK3B | |
| SCHEMBL21601510 | 0.77 | ADORA3 (0.69) | MEN1KMT2ABLMGSK3AGSK3B | |
| SCHEMBL21601563 | 0.77 | ADORA3 (0.69) | MEN1KMT2ABLMGSK3AGSK3B | |
| SCHEMBL4917250 | 0.76 | ADORA3 (0.49) | MEN1KMT2ASYKADORA3ADORA2A | |
| SCHEMBL13301201 | 0.76 | FLT3 (0.53) | SYKADORA3ADORA2AADORA1PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8580763-B2 | 2, 6-dinitrogen-containing substituted purine derivatives, the preparation and uses thereof | ZHANGGUI WU (CN) | 2013-11-12 | — | — | US | disclosed |
| US-8580763-B2 | 2, 6-dinitrogen-containing substituted purine derivatives, the preparation and uses thereof | ZHANGGUI WU (CN) | 2013-11-12 | — | — | US | disclosed |
| US-20100144663-A1 | 2, 6-Dinitrogen-Containing Substituted Purine Derivatives, The Preparation And Uses Thereof | ZHE JIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY (CN) | 2010-06-10 | — | — | US | disclosed |
| US-20100144663-A1 | 2, 6-Dinitrogen-Containing Substituted Purine Derivatives, The Preparation And Uses Thereof | ZHE JIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY (CN) | 2010-06-10 | — | — | US | disclosed |
| EP-2149574-A1 | 2, 6-DINITROGEN-CONTAINING SUBSTITUTED PURINE DERIVATIVES, THE PREPARATION AND USES THEREOF | ZheJiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory (CN) | 2010-02-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144663-A1 | 2, 6-Dinitrogen-Containing Substituted Purine Derivatives, The Preparation And Uses Thereof | PNP, NUDT1, DPYD | MEN1 1653/4885KMT2A 2098/4885MAPT 3712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.