Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | GCGR | P47871 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
| ▸ | GABRD | O14764 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18557563 | 0.89 | MEN1 (0.49) | CA1CA2MAOBAURKAAURKB | |
| SCHEMBL13176931 | 0.84 | MAP4K4 (0.50) | ABL1HPGDMAP4K4MEN1KMT2A | |
| SCHEMBL29473775 | 0.83 | CA1 (0.51) | CA1CA2MAOBAURKAAURKB | |
| SCHEMBL13932512 | 0.81 | ACHE (0.54) | CA1CA2MAOBABL1ABCB1 | |
| SCHEMBL16574039 | 0.81 | MAOB (0.53) | MAOBALDH1A1MAPK14GCGRMAPT | |
| SCHEMBL10389844 | 0.80 | MAP4K4 (0.47) | ABL1HPGDALDH1A1MAP4K4MEN1 | |
| SCHEMBL7690453 | 0.80 | CA1 (0.49) | CA1CA2MAOBAURKAAURKB | |
| SCHEMBL14301863 | 0.78 | MEN1 (0.52) | CA1CA2MAOBAURKAAURKB | |
| SCHEMBL23419746 | 0.77 | ALDH1A1 (0.48) | CA1CA2MAOBAURKAAURKB | |
| SCHEMBL16574156 | 0.77 | L3MBTL1 (0.48) | ABL1MAPK14GCGRTP53MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3674303-A1 | NOVEL TRYPTOPHAN HYDROXYLASE INHIBITOR AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | Gwangju Institute of Science and Technology (KR) | 2020-07-01 | — | — | EP | disclosed |
| WO-2019039905-A1 | NOVEL TRYPTOPHAN HYDROXYLASE INHIBITOR AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | 광주과학기술원 | 2019-02-28 | — | — | WO | disclosed |
| US-20100144516-A1 | PREPARATION AND USE OF MAGNESIUM AMIDES | LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN (DE) | 2010-06-10 | — | — | US | disclosed |