Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2760280 | 0.85 | FKBP1A (0.56) | KEAP1NFE2L2NPC1 | |
| SCHEMBL13842603 | 0.85 | KMT2A (0.51) | KEAP1NFE2L2PARP14NPC1 | |
| SCHEMBL11561858 | 0.83 | FKBP1A (0.54) | KEAP1NFE2L2NPC1 | |
| SCHEMBL12900927 | 0.82 | MEN1 (0.49) | PTGS1PTGS2KEAP1NFE2L2PARP14 | |
| SCHEMBL19420697 | 0.82 | TP53 (0.45) | PTGS1PTGS2KEAP1NFE2L2PARP14 | |
| SCHEMBL13855804 | 0.82 | — | — | |
| SCHEMBL15073123 | 0.82 | APP (0.59) | PTGS1PTGS2KEAP1NFE2L2PARP14 | |
| SCHEMBL14014069 | 0.82 | KDM1A (0.49) | KEAP1NFE2L2PARP14NPC1LMNA | |
| SCHEMBL1290883 | 0.82 | KMT2A (0.49) | KEAP1NFE2L2NPC1LMNAHPGD | |
| SCHEMBL1290875 | 0.82 | KEAP1 (0.43) | PTGS1PTGS2KEAP1NFE2L2PARP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859778-B2 | 1-phenyl-2-pyridinyl alkyl alcohol compounds as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-10-14 | — | — | US | disclosed |
| US-20140179647-A1 | 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-06-26 | — | — | US | disclosed |
| US-8648204-B2 | 1-phenyl-2-pyridinyl alkyl alcohol compounds as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179647-A1 | 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS | PDE4A, PDE4B, PDE3A | PTGS1 77/4885PTGS2 208/4885KEAP1 2158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.