Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.46 |
| ▸ | CDK2 | P24941 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 5/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13288943 | 0.85 | BRD4 (0.44) | GSK3BCDK2ALDH1A1MAPTMAPK1 | |
| SCHEMBL14418845 | 0.84 | ALDH1A1 (0.43) | GSK3BCDK2ALDH1A1MAPTMAPK1 | |
| SCHEMBL13120284 | 0.83 | CDK2 (0.60) | GSK3BCDK2KMT2A | |
| SCHEMBL13304619 | 0.82 | GSK3B (0.55) | GSK3BCDK2ALDH1A1MAPTMAPK1 | |
| SCHEMBL13120304 | 0.81 | CDK2 (0.58) | GSK3BCDK2 | |
| SCHEMBL13288754 | 0.81 | CDK2 (0.45) | GSK3BCDK2MAPTMEN1KMT2A | |
| SCHEMBL13120278 | 0.81 | GSK3B (0.57) | GSK3BCDK2MAPTMEN1KMT2A | |
| SCHEMBL13120285 | 0.81 | GSK3B (0.57) | GSK3BCDK2 | |
| SCHEMBL13288895 | 0.81 | GSK3B (0.43) | GSK3BCDK2ALDH1A1MAPTMAPK1 | |
| SCHEMBL14043329 | 0.80 | KISS1R (0.38) | GSK3BCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |