Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 4/20 | 0.41 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13305685 | 0.91 | MAP3K12 (0.43) | MAPK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL12953762 | 0.91 | GSK3B (0.51) | MAPK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL13305009 | 0.85 | USP30 (0.45) | MAPK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL12953558 | 0.83 | GSK3B (0.50) | MAPK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL13305198 | 0.80 | GSK3B (0.56) | GSK3BCHEK1CDK2GRIN2BCYP2D6 | |
| SCHEMBL14043203 | 0.80 | TRPC3 (0.44) | USP30GSK3BCHEK1CCNA2CDK2 | |
| SCHEMBL12953266 | 0.80 | GSK3B (0.51) | JAK2JAK1TYK2JAK3USP30 | |
| SCHEMBL12954179 | 0.80 | GSK3B (0.67) | GSK3BCDK2 | |
| SCHEMBL13304833 | 0.79 | CA2 (0.52) | USP30GSK3BGRIN2BENPP2CYP2D6 | |
| SCHEMBL13304821 | 0.79 | GSK3B (0.53) | GSK3BCHEK1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |