Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 2/20 | 0.44 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12953650 | 0.91 | GSK3B (0.54) | TRPC3TRPC7USP30GSK3BGRIN2B | |
| SCHEMBL13304833 | 0.89 | CA2 (0.52) | TRPC3TRPC7USP30GSK3BGRIN2B | |
| SCHEMBL13305198 | 0.89 | GSK3B (0.56) | TRPC3TRPC7GSK3BGRIN2BCYP2D6 | |
| SCHEMBL13305170 | 0.88 | TRPC3 (0.43) | TRPC3TRPC7USP30GSK3BGRIN2B | |
| SCHEMBL13305093 | 0.84 | TRPC3 (0.41) | TRPC3TRPC7USP30GSK3BGRIN2B | |
| SCHEMBL12954207 | 0.83 | GSK3B (0.51) | TRPC3TRPC7USP30GSK3BGRIN2B | |
| SCHEMBL12953919 | 0.82 | TRPC3 (0.53) | TRPC3TRPC7USP30GRIN2BCYP2D6 | |
| SCHEMBL13305133 | 0.82 | TRPC3 (0.53) | TRPC3TRPC7USP30GRIN2BCYP2D6 | |
| SCHEMBL12953550 | 0.81 | GSK3B (0.52) | TRPC3TRPC7GSK3BGRIN2BCYP2D6 | |
| SCHEMBL12953476 | 0.81 | GSK3B (0.52) | TRPC3TRPC7GSK3BGRIN2BCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130570-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |