Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PSD | A5PKW4 | 2/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.34 |
| ▸ | CDK2 | P24941 | 6/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.34 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | CTSS | P25774 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13305063 | 0.82 | PSD (0.40) | GSK3BALDH1A1MAPTSMN1; SMN2PSD | |
| SCHEMBL12953240 | 0.80 | GSK3B (0.55) | GSK3BALDH1A1MAPTSMN1; SMN2PSD | |
| SCHEMBL13304791 | 0.80 | GSK3B (0.39) | GSK3BALDH1A1MAPTSMN1; SMN2PSD | |
| SCHEMBL12953531 | 0.79 | CHEK1 (0.55) | GSK3BALDH1A1MAPTSMN1; SMN2PSD | |
| SCHEMBL14516424 | 0.75 | CHEK1 (0.58) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL13305054 | 0.73 | TRPC3 (0.53) | ALDH1A1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL29174808 | 0.71 | ALDH1A1 (0.41) | GSK3BALDH1A1MAPTSMN1; SMN2CHEK1 | |
| SCHEMBL5466448 | 0.69 | PDE10A (0.56) | GSK3BALDH1A1SMN1; SMN2PSDCHEK1 | |
| SCHEMBL13298010 | 0.68 | KDM4E (0.41) | PSDTLR8CTSKCTSSKDM4E | |
| SCHEMBL13305024 | 0.68 | HSP90AA1 (0.41) | GSK3BALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |