Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 10/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.36 |
| ▸ | CDK2 | P24941 | 8/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 8/20 | 0.36 |
| ▸ | PSD | A5PKW4 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13305063 | 0.83 | PSD (0.40) | GSK3BALDH1A1MAPTSMN1; SMN2CHEK1 | |
| SCHEMBL14043149 | 0.83 | CHEK1 (0.52) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL12953240 | 0.83 | GSK3B (0.55) | GSK3BALDH1A1MAPTSMN1; SMN2CHEK1 | |
| SCHEMBL13304699 | 0.81 | KDM4E (0.31) | ALDH1A1MAPT | |
| SCHEMBL13304835 | 0.81 | ALDH1A1 (0.31) | ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL13304840 | 0.80 | GSK3B (0.38) | GSK3BALDH1A1MAPTSMN1; SMN2CHEK1 | |
| SCHEMBL12953531 | 0.80 | CHEK1 (0.55) | GSK3BALDH1A1MAPTSMN1; SMN2CHEK1 | |
| SCHEMBL13304711 | 0.77 | HTR6 (0.35) | GSK3B | |
| SCHEMBL14516424 | 0.76 | CHEK1 (0.58) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL5466448 | 0.75 | PDE10A (0.56) | GSK3BALDH1A1SMN1; SMN2CHEK1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |