Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.62 |
| ▸ | AXL | P30530 | 9/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.57 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.56 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.52 |
| ▸ | TTK | P33981 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 6/20 | 0.50 |
| ▸ | FLT1 | P17948 | 6/20 | 0.50 |
| ▸ | KIT | P10721 | 5/20 | 0.50 |
| ▸ | AURKA | O14965 | 4/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.50 |
| ▸ | STK3 | Q13188 | 4/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.50 |
| ▸ | PLK4 | O00444 | 3/20 | 0.50 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1332041 | 0.95 | KDR (0.69) | KDRAXLFGFR1DDR2NTRK1 | |
| SCHEMBL1330301 | 0.85 | AXL (0.60) | KDRAXLFGFR1DDR2NTRK1 | |
| SCHEMBL1331695 | 0.85 | AURKB (0.61) | KDRAXLFGFR1DDR2NTRK1 | |
| SCHEMBL1331637 | 0.84 | KDR (0.64) | KDRAXLFGFR1DDR2NTRK1 | |
| SCHEMBL1329799 | 0.83 | KDR (0.66) | KDRAXLFGFR1NTRK1MAP2K7 | |
| SCHEMBL1330237 | 0.83 | FGFR1 (0.70) | KDRAXLFGFR1DDR2NTRK1 | |
| SCHEMBL1330072 | 0.82 | KDR (0.75) | KDRAXLFGFR1NTRK1MAP2K7 | |
| SCHEMBL1331850 | 0.81 | FGFR1 (0.64) | AXLFGFR1DDR2NTRK1TTK | |
| SCHEMBL1330136 | 0.81 | AXL (0.62) | KDRAXLFGFR1DDR2AURKB | |
| SCHEMBL1331362 | 0.81 | FGFR1 (0.62) | KDRAXLFGFR1DDR2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569301-A1 | INDAZOLE INHIBITORS OF KINASE | Abbvie Inc. (US) | 2013-03-20 | — | — | EP | disclosed |
| US-8293738-B2 | Indazole inhibitors of kinase | ABBOTT LABORATORIES (US) | 2012-10-23 | — | — | US | disclosed |
| US-20110281868-A1 | INDAZOLE INHIBITORS OF KINASE | ABBOTT LABORATORIES (US) | 2011-11-17 | — | — | US | disclosed |
| WO-2011143430-A1 | INDAZOLE INHIBITORS OF KINASE | ABBOTT LABORATORIES (US) | 2011-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281868-A1 | INDAZOLE INHIBITORS OF KINASE | AURKA, AURKC, AURKB | KDR 11/4885AXL 399/4885FGFR1 227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.