Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 3/20 | 0.53 |
| ▸ | TRPC7 | Q9HCX4 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12953919 | 0.89 | TRPC3 (0.53) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A | |
| SCHEMBL13305198 | 0.82 | GSK3B (0.56) | TRPC3TRPC7GRIN2BCYP2D6CYP2C9 | |
| SCHEMBL14043203 | 0.82 | TRPC3 (0.44) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A | |
| SCHEMBL13305058 | 0.81 | TRPC3 (0.57) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A | |
| SCHEMBL13305009 | 0.79 | USP30 (0.45) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A | |
| SCHEMBL13901218 | 0.79 | TRPC3 (0.53) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A | |
| SCHEMBL13304833 | 0.79 | CA2 (0.52) | TRPC3TRPC7SMN1; SMN2RAB9ACYP2C19 | |
| SCHEMBL13993128 | 0.78 | TRPC3 (0.49) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A | |
| SCHEMBL13901344 | 0.78 | TRPC3 (0.53) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A | |
| SCHEMBL12953546 | 0.78 | TRPC3 (0.53) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |