Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13309461 | 0.88 | KDM4E (0.44) | KDM4ETP53POLBGSK3BALDH1A1 | |
| SCHEMBL13308747 | 0.88 | KDM4E (0.44) | KDM4ETP53POLBGSK3BALDH1A1 | |
| SCHEMBL14528871 | 0.86 | KDM4E (0.43) | KDM4ETP53POLBGSK3BALDH1A1 | |
| SCHEMBL11931065 | 0.86 | GSK3B (0.56) | KDM4ETP53POLBGSK3BALDH1A1 | |
| SCHEMBL13309241 | 0.86 | GSK3B (0.46) | KDM4ETP53POLBGSK3BALDH1A1 | |
| SCHEMBL14528898 | 0.82 | KDM4E (0.41) | KDM4ETP53POLBGSK3BALDH1A1 | |
| SCHEMBL13309116 | 0.81 | ALDH1A1 (0.49) | KDM4ETP53POLBALDH1A1MAPK1 | |
| SCHEMBL14528759 | 0.81 | IKBKB (0.42) | KDM4ETP53POLBGSK3BMAPK1 | |
| SCHEMBL13309050 | 0.81 | ALDH1A1 (0.47) | KDM4ETP53POLBGSK3BALDH1A1 | |
| SCHEMBL13885078 | 0.81 | GSK3B (0.59) | KDM4ETP53POLBGSK3BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934224-B1 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS FOR THE TREATMENT OF CANCER | SCHERING CORP (US) | 2010-06-09 | — | — | EP | disclosed |