Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13885130 | 0.88 | ALDH1A1 (0.48) | ALDH1A1KDM4EKMT2ANPC1MAPT | |
| SCHEMBL14528759 | 0.85 | IKBKB (0.42) | KDM4EKMT2ANPC1MAPTRAB9A | |
| SCHEMBL13309052 | 0.81 | KDM4E (0.43) | ALDH1A1KDM4EKMT2ANPC1MAPT | |
| SCHEMBL13309461 | 0.79 | KDM4E (0.44) | ALDH1A1KDM4EKMT2ANPC1MAPT | |
| SCHEMBL13309241 | 0.78 | GSK3B (0.46) | ALDH1A1KDM4EKMT2ANPC1MAPT | |
| SCHEMBL13308747 | 0.78 | KDM4E (0.44) | ALDH1A1KDM4EKMT2ANPC1MAPT | |
| SCHEMBL14528803 | 0.78 | KMT2A (0.39) | ALDH1A1KDM4EKMT2ANPC1MAPT | |
| SCHEMBL14528898 | 0.75 | KDM4E (0.41) | ALDH1A1KDM4EKMT2ANPC1RAB9A | |
| SCHEMBL14528735 | 0.74 | KDM4E (0.43) | ALDH1A1KDM4EKMT2ANPC1MAPT | |
| SCHEMBL13885081 | 0.74 | GSK3B (0.53) | ALDH1A1KDM4EKMT2ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934224-B1 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS FOR THE TREATMENT OF CANCER | SCHERING CORP (US) | 2010-06-09 | — | — | EP | disclosed |