Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 4/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13309059 | 0.88 | IKBKB (0.44) | IKBKBKDM4ENPC1MAPTMAPK1 | |
| SCHEMBL11931067 | 0.88 | GSK3B (0.53) | IKBKBKDM4ENPC1MAPTMAPK1 | |
| SCHEMBL14528803 | 0.85 | KMT2A (0.39) | KDM4ENPC1MAPTMAPK1RAB9A | |
| SCHEMBL13309116 | 0.85 | ALDH1A1 (0.49) | KDM4ENPC1MAPTMAPK1RAB9A | |
| SCHEMBL11931064 | 0.84 | GSK3B (0.55) | IKBKBKDM4ENPSR1CDK2CDK1 | |
| SCHEMBL13309125 | 0.83 | GSK3B (0.48) | IKBKBKDM4ENPC1MAPTMAPK1 | |
| SCHEMBL13309241 | 0.81 | GSK3B (0.46) | KDM4ENPC1MAPTMAPK1RAB9A | |
| SCHEMBL13309052 | 0.81 | KDM4E (0.43) | KDM4ENPC1MAPTMAPK1RAB9A | |
| SCHEMBL13309461 | 0.80 | KDM4E (0.44) | KDM4ENPC1MAPTMAPK1RAB9A | |
| SCHEMBL13308747 | 0.80 | KDM4E (0.44) | KDM4ENPC1MAPTMAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534712-B1 | PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2007-05-16 | — | — | EP | disclosed |