Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.66 |
| ▸ | NPC1 | O15118 | 3/20 | 0.66 |
| ▸ | RAB9A | P51151 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | SCD | O00767 | 2/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.51 |
| ▸ | CKS1B | P61024 | 2/20 | 0.51 |
| ▸ | SKP1 | P63208 | 2/20 | 0.51 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1330690 | 0.90 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL24641499 | 0.84 | DDB1 (0.54) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL1331055 | 0.84 | RAB9A (0.77) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL7703129 | 0.83 | RAB9A (0.75) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL31185132 | 0.82 | TBK1 (0.58) | SMN1; SMN2MAPTTSHRNPSR1HTT | |
| SCHEMBL25183161 | 0.82 | TBK1 (0.58) | SMN1; SMN2MAPTTSHRNPSR1HTT | |
| SCHEMBL3672660 | 0.82 | RAB9A (0.67) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL26633205 | 0.81 | HRH3 (0.59) | SMN1; SMN2MAPTTSHRHDAC1TBK1 | |
| SCHEMBL30385900 | 0.81 | HRH3 (0.59) | SMN1; SMN2MAPTTSHRHDAC1TBK1 | |
| SCHEMBL19580854 | 0.81 | HDAC1 (0.57) | SMN1; SMN2NPC1RAB9AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110281871-A1 | TAAR1 LIGANDS | GALLEY GUIDO (DE) | 2011-11-17 | — | — | US | disclosed |
| US-8008305-B2 | TAAR1 ligands | HOFFMANN-LA ROCHE INC. (US) | 2011-08-30 | — | — | US | disclosed |
| EP-2185502-A1 | PYRIDINECARBOXAMIDE AND BENZAMIDE DERIVATIVES AS TAAR1 LIGANDS | F. Hoffmann-Roche AG (CH) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009019149-A1 | PYRIDINECARBOXAMIDE AND BENZAMIDE DERIVATIVES AS TAAR1 LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-12 | — | — | WO | disclosed |
| US-20090036452-A1 | TAAR1 LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036452-A1 | TAAR1 LIGANDS | TAAR1, TAAR5, NPSR1 | SMN1; SMN2 2022/4885NPC1 1378/4885RAB9A 2200/4885 |
| US-20110281871-A1 | TAAR1 LIGANDS | TAAR1, TAAR5, NPSR1 | SMN1; SMN2 2022/4885NPC1 1378/4885RAB9A 2200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.