Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FURIN | P09958 | 3/20 | 0.36 |
| ▸ | FAP | Q12884 | 5/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPY1R | P25929 | 2/20 | 0.32 |
| ▸ | NPY4R | P50391 | 2/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA4 | P22748 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13311080 | 0.99 | FURIN (0.36) | FURINFAPOPRK1HTTNPY1R | |
| SCHEMBL13310984 | 0.92 | FAP (0.36) | FURINFAPOPRK1HTTNPY1R | |
| SCHEMBL14012282 | 0.91 | FURIN (0.41) | FURINFAPOPRK1HTTNPY1R | |
| SCHEMBL13311091 | 0.91 | HTT (0.35) | FURINFAPOPRK1HTTNPY1R | |
| SCHEMBL16285990 | 0.90 | FURIN (0.37) | FURINFAPHTTSIRT2SIRT1 | |
| SCHEMBL13805702 | 0.88 | FURIN (0.32) | FURINFAPOPRK1NPY1RNPY4R | |
| SCHEMBL19026373 | 0.87 | FAP (0.39) | FURINFAPOPRK1HTTSIRT2 | |
| SCHEMBL16327728 | 0.87 | FAP (0.42) | FURINFAPOPRK1SIRT2SIRT1 | |
| SCHEMBL24898929 | 0.87 | FAP (0.39) | FURINFAPOPRK1HTTNPY1R | |
| SCHEMBL19026412 | 0.87 | FAP (0.39) | FURINFAPOPRK1HTTNPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8664407-B2 | Chemical linkers with single amino acids and conjugates thereof | Medarex, LLC (US) | 2014-03-04 | — | — | US | disclosed |
| US-20100145036-A1 | CHEMICAL LINKERS AND CLEAVABLE SUBSTRATES AND CONJUGATES THEREOF | MEDAREX, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| US-20100145036-A1 | CHEMICAL LINKERS AND CLEAVABLE SUBSTRATES AND CONJUGATES THEREOF | MEDAREX, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| US-20100113476-A1 | CHEMICAL LINKERS WITH SINGLE AMINO ACIDS AND CONJUGATES THEREOF | E. R. SQUIBB & SONS, L.L.C. | 2010-05-06 | — | — | US | disclosed |
| US-20100113476-A1 | CHEMICAL LINKERS WITH SINGLE AMINO ACIDS AND CONJUGATES THEREOF | E. R. SQUIBB & SONS, L.L.C. | 2010-05-06 | — | — | US | disclosed |
| WO-2008103693-A2 | CHEMICAL LINKERS WITH SINGLE AMINO ACIDS AND CONJUGATES THEREOF | MEDAREX, INC. (US) | 2008-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113476-A1 | CHEMICAL LINKERS WITH SINGLE AMINO ACIDS AND CONJUGATES THEREOF | DNPEP, ANTXR2, CLSPN | FURIN 449/4885FAP 1295/4885OPRK1 2019/4885 |
| US-20100145036-A1 | CHEMICAL LINKERS AND CLEAVABLE SUBSTRATES AND CONJUGATES THEREOF | XIAP, ADAM8, CLSPN | FURIN 43/4885FAP 929/4885OPRK1 4075/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.