ADAM8 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL3947078	0.61	4/20
SCHEMBL7421462	0.61	4/20
SCHEMBL3944138	0.57	4/20
SCHEMBL7423135	0.57	4/20
SCHEMBL4372331	0.57	4/20
SCHEMBL3942829	0.57	4/20
SCHEMBL3940966	0.55	4/20
SCHEMBL3944147	0.55	4/20
SCHEMBL6530081	0.55	4/20
SCHEMBL6864328	0.55	4/20
SCHEMBL3940904	0.54	4/20
SCHEMBL3942100	0.54	4/20
SCHEMBL6503539	0.54	4/20
SCHEMBL3872450	0.54	4/20
SCHEMBL3938317	0.54	4/20
SCHEMBL1799058	0.54	4/20
SCHEMBL3948447	0.53	4/20
SCHEMBL3939484	0.53	4/20
SCHEMBL3940147	0.53	4/20
SCHEMBL7419812	0.53	4/20

Clinical trials — most relevant to ADAM8 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Estimation of MMP-8 Levels in GCF and Serum and Its Correlation With Wound Healing and Clinical Outcomes After Coronally Advanced Flap and Subepithelial Connective Tissue Graft for Root Coverage in Recession Defects: A CLINICO-BIOCHEMICAL STUDY	PHASE4	SUSPENDED
Sputum Matrix Metalloproteinases (MMP) mRNA and Montelukast	PHASE2	COMPLETED
A Study of IDN-6556 in Subjects With Liver Cirrhosis	PHASE2	COMPLETED
The Role of Matrix Metalloproteinases (MMPs) in Orthodontic Tooth Movement	PHASE1	COMPLETED
Phase 1 Dose Escalation, Single Dose Study to Assess Safety and Pharmacokinetics of BAX930 in Hereditary Thrombotic Thrombocytopenic Purpura (TTP)	PHASE1	COMPLETED
Role of A Disintegrin and Metalloproteinase (ADAM) in Epithelial Dysfunction	nan	COMPLETED
Apoptotic Changes in Gingiva Caused by Smoking	nan	COMPLETED
Exercise and the Receptor for Advanced Glycation End Products (RAGE)	nan	COMPLETED
Peri-implantitis and MMP-8	nan	COMPLETED
Early Diagnosis and Prognosis of Postoperative Sepsis by Presepsin and Syndecan-1	nan	UNKNOWN
Evaluation of Different Serum Cartilage Biomarkers in the Acute Response to Walking and Cycling in Healthy Male Subjects	nan	AVAILABLE
Analysis of the Variation in Caspase-8 Availability and Cleavage in Oral Squamous Cell Carcinoma	nan	UNKNOWN
Association Between Matrix Metalloproteinase-2 Gene Polymorphism rs243865 and Susceptibility to Cataract Development	nan	COMPLETED
Extracellular Matrix Remodeling of the Umbilical Cord and Placenta in Preeclampsia	nan	UNKNOWN
Diagnostic Accuracy of Rapid Non-clinical Screening Tests for Early Detection of Periodontitis	nan	COMPLETED
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
The Effects of Sodium Fluoride and Chlorhexidine Use on Salivary IL-6 and Matrix Metalloproteinase Levels in Children With Active Caries	nan	RECRUITING
Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma	nan	UNKNOWN
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure	nan	RECRUITING
Influence of Statins in Artery Aneurysms	nan	UNKNOWN
Infection, Sepsis and Meningitis in Surinamese Neonates	nan	COMPLETED
Immediate Implant Placement With Subepithelial Connective Tissue Grafting and Probiotics	nan	NOT_YET_RECRUITING
Salivary Markers in Periodontal Disorders	nan	COMPLETED
Improvement of Immunologic and Molecular Techniques for the Diagnosis and Follow-up of Patients With Thrombotic Thrombocytopenic Purpura	nan	ACTIVE_NOT_RECRUITING
Circulating Markers for Ischemic Heart Disease	nan	RECRUITING
Pharmacokinetics of Low Molecular Weight Heparin in Cancer Patients	nan	COMPLETED
Matrix Metalloproteinases After Surgery and/or Radiofrequency Ablation in Patients With Liver Metastases From Colorectal Cancer	nan	COMPLETED
Role of Circulating MicroRNAs in Pathogenesis of Aneurysms of the Abdominal and Thoracic Aorta - Study Micro AAA	nan	UNKNOWN
Biomarkers in Post Thrombotic Syndrome	nan	COMPLETED
Detection of Cancer-Specific Active Proteases in Blood Via Fluorescence	nan	WITHDRAWN

Related proteins — ESM-2 sequence neighbours (a ADAM8 binder may also engage these)

Protein	Name	Similarity
Q13444	—	0.995	Q13444 →
Q9TT93	—	0.994	Q9TT93 →
Q8BNJ2	—	0.992	Q8BNJ2 →
Q05910	—	0.991	Q05910 →
O35674	—	0.991	O35674 →
ADAM12	Disintegrin and metalloproteinase domain-containing protein 12	0.990	landscape →
Q61824	—	0.989	Q61824 →
ADAMTS4	A disintegrin and metalloproteinase with thrombospondin motifs 4	0.987	landscape →
Q5RFQ8	—	0.986	Q5RFQ8 →
Q9QYV0	—	0.985	Q9QYV0 →
O88839	—	0.985	O88839 →
Q9H013	—	0.984	Q9H013 →
ADAMTS7	A disintegrin and metalloproteinase with thrombospondin motifs 7	0.982	landscape →
P58459	—	0.981	P58459 →
Q9H324	—	0.981	Q9H324 →
Q8TE58	—	0.978	Q8TE58 →
Q8WXS8	—	0.978	Q8WXS8 →
ITGB7	Integrin beta-7	0.978	landscape →
P57110	—	0.978	P57110 →
Q9C0C4	—	0.977	Q9C0C4 →
Q9R0S3	—	0.976	Q9R0S3 →
P59384	—	0.976	P59384 →
Q9ESP7	—	0.975	Q9ESP7 →
F12	Coagulation factor XII	0.975	landscape →
P70505	—	0.974	P70505 →
Q8K1E3	—	0.974	Q8K1E3 →
Q9NS98	—	0.973	Q9NS98 →
ADAMTS1	A disintegrin and metalloproteinase with thrombospondin motifs 1	0.973	landscape →
Q68SA9	—	0.973	Q68SA9 →
MMP17	Matrix metalloproteinase-17	0.973	landscape →